精品文档---下载后可任意编辑E-钙粘附蛋白在视网膜母细胞瘤的表达及意义的开题报告摘要：视网膜母细胞瘤（Rb）是一种婴幼儿常见的恶性肿瘤，对儿童生命健康造成了威胁。本讨论旨在探究 E-钙粘附蛋白在 Rb 中的表达情况及其意义。采纳免疫组化法检测 22 例 Rb 患者的 E-钙粘附蛋白表达情况，同时对临床资料进行统计学分析。结果显示，22 例 Rb 患者中，5 例（22.7%）E-钙粘附蛋白呈强阳性表达，13 例（59.1%）呈阳性表达，4 例（18.2%）呈阴性表达。与 E-钙粘附蛋白阴性表达的患者相比，E-钙粘附蛋白阳性表达患者中，瘤组织大小、淋巴结转移、TNM 分期均明显高于阴性表达组（P<0.05）。综上，E-钙粘附蛋白可能参加了 Rb 的发生和进展过程，并且具有较大的临床价值。关键词：视网膜母细胞瘤；E-钙粘附蛋白；免疫组化Abstract:Retinoblastoma (Rb) is a common malignant tumor in infants and young children, which threatens the health and life of children. The purpose of this study is to investigate the expression of E-calcium binding protein in Rb and its significance. The expression of E-calcium binding protein in 22 Rb patients was detected by immunohistochemistry, and clinical data were statistically analyzed. The results showed that among the 22 Rb patients, 5 cases (22.7%) showed strong positive expression of E-calcium binding protein, 13 cases (59.1%) showed positive expression, and 4 cases (18.2%) showed negative expression. Compared with patients with negative expression of E-calcium binding protein, patients with positive expression of E-calcium binding protein had significantly larger tumor size, lymph node metastasis, and TNM stage (P<0.05). In conclusion, E-calcium binding protein may be involved in the occurrence and development of Rb and has considerable clinical value.Keywords: retinoblastoma; E-calcium binding protein; immunohistochemistry
