目录摘要....................................................................1关键词....................................................................1Abstract..................................................................1Keywords.................................................................2第一章绪论...............................................................21.1研究背景...........................................................21.2研究的目的及意义...................................................31.3在临床药物治疗中的发展趋势.........................................3第二章美沙拉嗪联合龟龙丸对UC大鼠结肠炎改善作用的观察....................42.1实验材料...........................................................42.1.1实验动物.....................................................42.1.2实验药品.....................................................42.1.3实验仪器.....................................................42.2实验方法...........................................................42.2.1分组、造模方法及给药方法.....................................42.2.2标本采集.....................................................52.2.3观察指标.....................................................5第三章美沙拉嗪联合龟龙丸改善结UC大鼠结肠炎的机制研究....................63.1实验材料...........................................................63.1.1实验动物.....................................................63.1.2实验药品.....................................................63.1.3实验仪器.....................................................63.2实验方法...........................................................63.2.1分组、造模方法及给药方法.....................................63.3.2标本采集.....................................................73.2.3观察指标.....................................................7第四章美沙拉嗪联合龟龙丸的临床药物试验观察...............................84.1临床资料...........................................................84.2治疗方法...........................................................84.3观察指标...........................................................94.4疗效标准...........................................................9第五章可行性论证.........................................................9第六章预期结果及分析.....................................................96.1美沙拉嗪联合龟龙丸对UC大鼠结肠炎改善作用的观察....................96.2美沙拉嗪联合龟龙丸对UC大鼠结肠炎机制的研究.......................106.3美沙拉嗪联合龟龙丸的临床药物试验观察..............................11参考文献.................................................................11致谢.....................................................................131美沙拉嗪联合龟龙丸对溃疡性结肠炎大鼠结肠炎的改善作用及其机制研究、摘要：目的是分析美沙拉嗪联合龟龙丸对溃疡性结肠炎大鼠结肠炎的改善作用和机制研究。方法是，运用2,4,6-三硝基苯磺酸(TNBS)与乙醇法诱导溃疡性结肠炎大鼠模型。将70只大鼠分为七组对照组，当然为了实验的准确，采用的是随机分配，结肠炎模型组，美沙拉嗪组，龟龙丸组，美沙拉嗪联合龟龙丸低剂量组、中剂量组、高剂量组。通过观察七组大鼠结肠炎粘膜完整性、测定大鼠血清IL-4和IL-6的浓度以及各项指数反映出美沙拉嗪联合龟龙丸对溃疡性结肠炎大鼠结肠炎的改善作用，并且通过检测各组大鼠结肠组织中TLR4、TRAF6、NF-κB蛋白表达水平、检测各组大鼠结肠组织中TLR4、TRAF6、TNF-α、NF-κBmRNA水平以及对各组大鼠血清中相...
