肠型白塞氏病临床病理特征分析3例VIP免费

wcjd@wjgnet.com世界华人消化杂志2009年6月8日;17(16):1689-1692ISSN1009-3079CN14-1260/R临床经验CLINICALPRACTICE肠型白塞氏病临床病理特征分析3例张淑坤,王建国,周世英,张梦岚,吴彩虹张淑坤,王建国,周世英,张梦岚,吴彩虹,青海省人民医院病理科青海省西宁市810007作者贡献分布:此课题由张淑坤与王建国设计;研究过程由周世英、张梦岚及吴彩虹完成;本论文写作由张淑坤、王建国、周世英、张梦岚及吴彩虹完成.通讯作者:张淑坤,主治医师,810007,青海省西宁市,青海省人民医院病理科.zhangshukun0475@yahoo.com.cn电话:0971-8066214收稿日期:2009-03-02修回日期:2009-04-11接受日期:2009-04-13在线出版日期:2009-06-08ClinicopathologicalfeaturesofintestinalBehcet’sdisease:ananalysisof3casesShu-KunZhang,Jian-GuoWang,Shi-YingZhou,Meng-LanZhang,Cai-HongWuShu-KunZhang,Jian-GuoWang,Shi-YingZhou,Meng-LanZhang,Cai-HongWu,DepartmentofPathology,Qin-ghaiProvincePeople’sHospital,Xining810007,QinghaiProvince,ChinaCorrespondenceto:Shu-KunZhang,DepartmentofPathology,QinghaiProvincialPeople’sHospital,Xining810007,China.zhangshukun0475@yahoo.com.cnReceived:2009-03-02Revised:2009-04-11Accepted:2009-04-13Publishedonline:2009-06-08AbstractAIM:Toexploretheclinicalandpathologicalfeatures,anddifferentialdiagnosisofintestinalBehcet’sdisease(BD).METHODS:ThreecasesofintestinalBDwerecollectedinthestudy.Theirclinicalandhisto-logicalfindingswereexamined.Thepatientsmetthediagnosticcriteriaproposedbythein-ternationalstudygroupofBD.Thepatientshadgastrointestinalsymptomsandwereaccompa-niedbyseveralmainBDfeatures.RESULTS:TheintestinalulcersofBDmostlyoccurredinthecontralateralofmesenteric,roundanddeep.Histologically,vascularandmucosaaroundintestinalulcerwereinfiltratedbythelymphocytes.Lymphoproliferationwasobserved,andmainlymanifestedasvasculitis.Glucocorticoidandimmunosuppressantwerethedominantprescriptions.Theprognosisofin-testinalBDremainedunsatisfactory.CONCLUSION:EarlydiagnosisofintestinalBDdependsoncomprehensiveanalysisofpatients’historyandclinicalsymptoms.ThereislackofspecifictreatmentforIntestinalBD.Generalsur-geryisunnecessarywiththeexceptionofseverecomplications.KeyWords:IntestinalBehcet’sdisease;Clinicalfea-tures;PathologicalfeaturesZhangSK,WangJG,ZhouSY,ZhangML,WuCH.ClinicopathologicalfeaturesofintestinalBehcet’sdisease:ananalysisof3cases.ShijieHuarenXiaohuaZazhi2009;17(16):1689-1692摘要目的:探讨肠型白塞氏病的临床特点、病理学特征及鉴别诊断要点.方法:收集肠型白塞氏病确诊患者3例,进行临床资料复习和组织病理学检查.患者均以消化系症状入院,同时患者伴有白塞氏病的主要临床症状.结果:患者溃疡病变多发生于肠系膜附着的对侧,溃疡呈圆形,较深;镜下见肠黏膜组织溃疡形成,周围黏膜下淋巴组织增生显著,主要表现以静脉为主的血管炎症.治疗上,糖皮质激素及免疫抑制剂是基础用药,其预后不令人满意.结论:肠型白塞氏病早期诊断有赖于对病史及临床症状的综合分析.肠型白塞氏病无特异性治疗方法,除非合并严重并发症,一般不主张手术治疗.关键词:肠型白塞氏病;临床特点;病理特点张淑坤,王建国,周世英,张梦岚,吴彩虹.肠型白塞氏病临床病理特征分析3例.世界华人消化杂志2009;17(16):1689-1692http://www.wjgnet.com/1009-3079/17/1689.asp0引言白塞氏病(Behcet'sdisease)是一种原因不明的多系统损害性疾病,该病以血管炎为病理基础,具www.wjgnet.com®■背景资料白塞氏是一种原因不明的多系统损害性疾病,合并肠道溃疡者又称为肠白塞氏病,为白塞氏病的特殊类型.近年本病报道呈上升趋势.为提高病理及临床医师对本病的认识,减少漏诊、误诊率,本文探讨其临床特点、病理学特征及鉴别诊断要点.■同行评议者张晓岚,教授,河北医科大学第二医院消化内科有一定的遗传...