精品文档---下载后可任意编辑2 型糖尿病患者乳腺癌易感基因 FGFR2 和 ZNF365多态性分析的开题报告【摘要】糖尿病和乳腺癌是两种常见疾病，且其发病率在全球范围内呈现上升趋势。讨论发现，2 型糖尿病患者患乳腺癌的风险高于非糖尿病患者。基因多态性是影响患者易感性的关键因素之一。本讨论旨在分析 2 型糖尿病患者乳腺癌易感基因 FGFR2 和 ZNF365 的多态性，明确与其发病相关的基因型和等位基因，并探讨其对患者乳腺癌风险的影响，为疾病的早期诊断和治疗提供参考。讨论将采纳 PCR 技术和基因序列分析方法，根据基因型和等位基因进行统计分析，并进行 t 检验和 Logistic 回归分析，探讨影响因素和关联性。估计结果有助于深化糖尿病和乳腺癌的遗传机制讨论，有重要的临床意义。【关键词】2 型糖尿病；乳腺癌；易感基因；多态性；PCR 技术；统计分析【Abstract】Diabetes and breast cancer are two common diseases, and their incidence is on the rise globally. Studies have found that the risk of breast cancer in type 2 diabetes patients is higher than that in non-diabetic patients. Gene polymorphism is one of the key factors affecting susceptibility of patients. The aim of this study is to analyze the polymorphism of breast cancer susceptibility genes FGFR2 and ZNF365 in type 2 diabetes patients, to clarify the relevant genotypes and alleles associated with its occurrence, and to explore its impact on breast cancer risk, providing reference for early diagnosis and treatment of the disease. The study will use PCR technology and gene sequencing analysis methods, statistical analysis according to genotypes and alleles, and conduct t-test and logistic regression analysis to explore the influencing factors and correlations. It is expected that the results will help deepen the genetic mechanism research of diabetes and breast cancer, and have important clinical significance.【Key words】Type 2 diabetes; Breast cancer; Susceptibility gene; Polymorphism; PCR technology; Statistical analysis
