精品文档---下载后可任意编辑CD86 是 NK 细胞的激活性受体的开题报告题目：CD86 是 NK 细胞的激活性受体摘要：CD86 是一种表达于抗原呈现细胞表面，与 CD80 具有相似功能的共刺激分子，它对于 T 细胞的激活有重要作用。近年来的讨论表明，CD86 在 NK 细胞中也具有激活性的作用，能够通过与其上的 CD28 或CTLA-4 等配体结合，激活 NK 细胞，参加体内免疫反应和肿瘤监视。本文首先介绍了 CD86 的基本结构、分布、功能和调控机制，然后综述了 CD86 在 NK 细胞中的作用及相应的分子信号途径，以及 CD86调节 NK 细胞参加肿瘤免疫治疗的潜在机制。最后，讨论了 CD86 在 NK细胞中的不足和争议，并提出了未来讨论方向的展望。关键词：CD86；NK 细胞；激活性受体；肿瘤免疫治疗Abstract：CD86 is a co-stimulatory molecule expressed on the surface of antigen-presenting cells, which has a similar function with CD80 in activating T cells. Recent studies have shown that CD86 also plays an activating role in NK cells, which can activate NK cells by binding to its ligands, such as CD28 or CTLA-4, and participate in the immune response and tumor surveillance in vivo.This article firstly introduces the basic structure, distribution, function and regulation mechanism of CD86, and then reviews the role of CD86 in NK cells and the corresponding molecular signaling pathway, as well as the potential mechanism of CD86 regulating NK cells in tumor immunotherapy. Finally, the deficiencies and controversies of CD86 in NK cells are discussed, and prospects for future research directions are proposed.Keywords: CD86; NK cell; activating receptor; tumor immunotherapy
