精品文档---下载后可任意编辑颞叶内侧癫痫致痫侧海马 CA1 区凋亡相关分子的表达及意义的开题报告摘要颞叶内侧癫痫（TLE）是一种常见的癫痫类型，其发病机制还不完全清楚。海马是 TLE 的重要病变部位之一，海马 CA1 区的神经元凋亡可能与 TLE 的进展相关。本讨论旨在探究颞叶内侧癫痫致痫侧海马 CA1 区神经元凋亡相关分子的表达及其意义。通过文献综述及实验讨论，发现TLE 患者海马 CA1 区神经元凋亡与多种因素相关，如 GABA 能神经元损伤、谷氨酸激活毒性机制、线粒体功能异常等。此外，一些基因和蛋白质的表达异常也被报道与海马 CA1 区神经元凋亡相关，如 Bcl-2 家族、caspase 家族、BDNF 等。这些分子的失衡导致了炎症反应及细胞凋亡的发生，从而参加了 TLE 的进展过程。本讨论可为 TLE 的临床诊治提供新的分子靶点及治疗方法。关键词：颞叶内侧癫痫；海马 CA1 区；神经元凋亡；表达谱；分子机制AbstractTemporal lobe epilepsy (TLE) is a common type of epilepsy whose pathogenesis is not fully understood. The hippocampus is an important lesion site in TLE, and hippocampal CA1 neuronal apoptosis may be related to the development of TLE. This study aims to explore the expression of apoptosis-related molecules in the hippocampal CA1 region of TLE and its significance. Through literature review and experimental research, it was found that the neuronal apoptosis in the hippocampal CA1 region of TLE patients is related to multiple factors, such as GABAergic neuronal injury, glutamate activation toxicity mechanism, mitochondrial dysfunction, etc. In addition, abnormal expression of some genes and proteins has also been reported to be related to hippocampal CA1 neuronal apoptosis, such as the Bcl-2 family, caspase family, BDNF, etc. The imbalance of these molecules leads to the occurrence of inflammatory reactions and cell apoptosis, thus participating in the development of TLE. This study can provide new molecular targets and treatment methods for the clinical diagnosis and treatment of TLE.精品文档---下载后可任意编辑Keywords: Temporal lobe epilepsy; hippocampal CA1 region; neuronal apoptosis; expression profile; molecular mechanism
