北京理工大学珠海学院布洛芬糖浆剂工艺设计题目：年产2000万支250ml糖浆剂生产车间工艺设计学生姓名：陈塨慧、苏泽鹏、萧志乐蔡权、冯宇学院：化工与材料学院专业班级：12应用化学2班2015年10月年产2000万支250ml糖浆剂生产车间工艺设计摘要依据GMP的思想，为布洛芬糖浆生产提供合理的生产工艺与车间布局。根据糖浆制剂车间设计的原则和规定科学有效地设计出年产2千万支250ml布洛芬糖浆的生产车间。对处方的设计、糖浆制剂工艺流程的设计以及物料衡算、工艺设备选型、车间设计和成本估算等进行了详细的研究和分析，并最终设计出有效可行的年产2千万支250ml布洛芬糖浆生产车间工艺。本设计严格遵守GMP规定，符合环保、经济、安全、技术等方面的要求。关键词：GMP；布洛芬糖浆；生产工艺；车间布局Anannualoutputof20million-250mlibuprofensyrupprocessdesignworkshopAbstractAccordingtothethoughtofGMP,providetheproductionprocessandworkshoplayoutreasonableforibuprofensyrupproduction.Accordingtotheprinciplesandprovisionsofthesyruppreparationworkshopdesignscienceeffectivelydesignanannualoutputof20millionpiecesof250mlofibuprofensyrupproductionworkshop.Theformulationdesign,injectionprocessdesignandthematerialbalance,processequipmentselection,workshopdesignandcostestimationofthedetailedresearchandanalysis.Andthefinaldesignofanannualoutputof20000000effective250mlibuprofensyrupproductionprocess.ThisdesignstrictlyabidebytheprovisionsofGMP,withtheenvironmentalprotection,economy,safety,technologyandotheraspectsoftherequest.Keywords:GMP；ibuprofensyrup；productionprocess；workshoplayout目录1前言...........................................................................11.1布洛芬糖浆剂的介绍......................................................11.1.1布洛芬的适应症....................................................11.1.2布洛芬的介绍......................................................11.1.3布洛芬的主要剂型..................................................21.1.4糖浆剂介绍........................................................21.1.5糖浆剂的特点......................................................21.1.6糖浆剂剂的分类....................................................21.1.7糖浆剂的规格和质量...............................................31.1.8糖浆剂在制备与贮藏过程中易出现的问题..............................32制剂规格、处方研究.............................................................42.1制剂规格设计............................................................42.2实验室制法..............................................................52.3处方分析................................................................52.3.1主药布洛芬的处方分析..............................................52.3.2粘度控制剂处方分析................................................62.3.3甜味剂............................................................62.3.4悬浮剂............................................................62.3.5乳化剂............................................................62.3.6PH控制剂.........................................................63工艺流程设计...................................................................73.1工艺流程图..............................................................74物料衡算.......................................................................74.1参数设计................................................................84.2原辅料物料衡算..........................................................84.3各工序物料进出计算.............
