不同基质配比对青辛速释贴质量的影响VIP专享VIP免费

表9HP—Innowax柱上姜黄挥发油GC谱8主峰保留指数数据Table9RetentionindicesofeightmainpeaksinGCchromatogramsofessentialoilinC.longaobtainedwithHP—Innowax柱前压/kPa升温速率/(℃·min-1)保留指数1234567880415851723172917761782219322572272704159017251731177817842197226122778031572171617211769177621852247226370315771719172417721778218822502266平均相对保留值15811721172617741780219122542270RSD/%0.510.230.260.230.210.240.280.28图2姜黄挥发油HP—Innowax柱GC程序升温测定图谱Fig.2GCchromatogramofessentialoilinC.longaobtainedwithHP—InnowaxReferences:[1]RegulationsfortheEstablishmentoftheFingerprintSpectraStandardoftheTCMInjections(Draft)(中药注射剂指纹图谱研究的技术要求(暂行)[S].2000.[2]HongXK,WangZH,GuoJX,etal.Thefingerprintspec-trumanalysisofGCrelativeretentionvaluesforessentialoilof19speciesofBupleurumGenus[J].ActaPharmSin(药学学报),1988,23(11):839-845.[3]KovatsE.GaschromatographiccharacterizationoforganiccompoundsⅠ.Retentionindexesofaliphatichalides,alco-hols,aldehydesandketones[J].HelvChimActa,1958,41:1915.[4]VanDenDoolH,KratzPD.Ageneralizationoftheretentionindexsystemincludinglineartemperatureprogrammedgas-liquidpartitionchromatography[J].JChromatogr,1963,11:463.不同基质配比对青辛速释贴质量的影响郑国1,罗光亮2,彭荣珍1�(1.暨南大学医学院第六附属医院江门市五邑中医院,广东江门529031;2.深圳市福田区中医院,广东深圳518034)摘要:目的选择以明胶、西黄蓍胶、甘油、聚丙烯酸钠和青黛制备青辛速释贴的最佳基质配比。方法应用正交试验法,分别以粘度、软硬度、清凉感和刺痛感为衡量指标,综合评定不同基质配比下青辛速释贴的质量。结果青辛速释贴的最佳基质配比为明胶∶西黄蓍胶∶甘油∶聚丙烯酸钠∶青黛(8.0∶3.5∶20∶1.3∶3.0)。结论采用青辛速释贴的最佳基质配比可制备质量较佳的青辛速释贴。关键词:青辛速释贴;基质;正交试验中图分类号:R283.6文献标识码:B文章编号:02532670(2003)09079703EffectofdifferentproportionofmatrixonqualityofQingxinSushiTieZHENGGuo-shen1,LUOGuang-liang2,PENGRong-zhen1(1.SixthAffiliatedHospital,WuyiHospitalofTCM,MedicalCollegeofJinanUniversity,Jiangmen529031,China;2.FutianHospitalofTCMinShenzhen,Shenzhen518034,China)Abstract:ObjectToselecttheoptimumproportionofmatrixforthepreparationprocessofQingxinSushiTie(QST)bygelatia,gumtragacanth,glycerol,sodiumacylateandQingdai.MethodsThepro-cesswasstudiedbyorthogonaltestwithviscosity,softandhardmeasurementalgefacientsentation,twingesentationasdetectivemarker.ThequalityofQSTwascomprehensivelycomparedbythedifferentproportionofmatrix.ResultsTheoptimumproportionofmatrixinQSTwasgelatia-gumtyagacanth-·797·中草药ChineseTraditionalandHerbalDrugs第34卷第9期2003年9月�收稿日期:2002-11-01基金项目:广东省中医药管理局立项课题(099628)作者简介:郑国(1964—),广东江门人,副主任药师,主要从事中成药的生产管理和开发研究,在省级以上的学术期刊发表论文23篇。Tel:(0750)3528288-3136glycerol-sodiumacylate-Qindai(8.0∶3.5∶20∶1.3∶3.0).ConclusionAccordingtotheoptimumpro-portionofmatrixinQST,theQSTwithbetterqualitycanbeprepared.Keywords:QingxinSushiTie(QST);matrix;orthogonaltest青辛速释贴由青黛、烟草和细辛组成,可缓解寒热感冒,对小儿感冒初起、缓缓发热、全身酸软症效果较好。中药巴布剂是以水溶性高分子化合物或亲水性物质为基质,与中药或中药提取物制成的贴敷物,对皮肤的生物相溶性、亲和性、透气性、耐汗和重复揭扯性均好,且不易过敏。青辛速释贴,可免除儿童对口服给药的恐惧感和注射给药的痛苦。在中药巴布剂的制备过程中,影响巴布剂成型的因素很多,有原料、基质药物比、调制次序和炼合温度等。在青辛方中,青黛不溶于水,须以原粉...