卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者NO、NOS、FIB、D-dimer及泌乳功能的影响[摘要]目的：研究卡前列素氨丁三醇联合卡贝缩宫素对剖宫产后出血患者一氧化氮（NO）、一氧化氮合酶（NOS）、纤维蛋白原(FIB)、D-二聚体(D-dimer)及泌乳功能的影响。方法：选取我院2015年6月至2017年6月具有剖宫产手术指证的孕产妇119例，分为观察组和对照组，对照组给予注射卡前列素氨丁三醇治疗，观察组给予注射卡前列素氨丁三醇联合卡贝缩宫素治疗。观察两组治疗后临床疗效，并检测治疗前后NO、NOS、FIB、D-dimer水平以及泌乳功能。结果：治疗后，观察组子宫复旧有效率为93.2%明显高于对照组子宫复旧有效率74.6%，差异显著（P<0.05）；观察组NO、NOS、FIB、D-dimer水平均显著低于对照组，比较具有统计学意义（P<0.05）；观察组术后2h出血量、术后24h出血量、产后出血率、宫缩持续时间及恶露持续时间均低于对照组，比较具有统计学意义（P<0.05）；观察组泌乳时间低于对照，观察组产后1d泌乳量评分及产后2d泌乳量评分均高于对照组，比较具有统计学意义（P<0.05）。结论:卡前列素氨丁三醇联合卡贝缩宫素治疗剖宫产产后出血患者，有效降低患者NO、NOS、FIB、D-dimer水平及2h出血量、术后24h出血量、产后出血率、宫缩持续时间及恶露持续时间，改善患者泌乳时间，提高患者1d泌乳量评分及产后2d泌乳量评分。【关键词】卡前列素氨丁三醇；卡贝缩宫素；NO；FIB；D-dimer；NOS；剖宫产产后出血中图分类号：R714.62文献标识码：A文章编号：EffectsofcaffeinetromethaminecombinedwithcarbeneoxytocinonNO,NOS,FIB,D-dimerandlactationinpatientswithpostpartumhemorrhage[Abstract]Objective:TostudyeffectsofcaffeinetromethaminecombinedwithcarbeneoxytocinonNO,NOS,FIB,D-dimerandlactationinpatientswithpostpartumhemorrhage.Methods:118patientsofcesareansectionbleedingwhoreceivedtherapyfromJune2015toJune2017inourhospitalwereselectedasresearchobjects.Accordingtodifferenttreatmentoptions，thosepatientsweredividedintothecontrolgroup(n=59)andtheobservationgroup(n=59)，thecontrolgroupwastreatedwithCardprostaglandintromethaminedrugtherapy,whiletheobservationgroupwastreatedwithProstaglandintromethaminecombinedwithcarbeneoxytocin,theclinicalefficacyofthetwogroupswasobservedandthelevelsofNO,NOS,FIB,D-dimerandlactationweremeasuredbeforeandaftertreatment.Results:Aftertreatment,theeffectiverateofuterinerecoverywas93.2%intheobservationgroup,whichwassignificantlyhigherthanthatinthecontrolgroup(74.6%).Thedifferencewassignificant(P<0.05).thelevelsofNO,NOS,FIBandD-dimerintheobservationgroupweresignificantlylowerthanthoseinthecontrolgroup(P<0.05).thetimeoflactationintheobservationgroupwaslowerthanthatinthecontrolgroup(P<0.05),andthetimeofpostoperativehemorrhage,postpartumhemorrhagerate,durationofuterinecontusionanddurationoflochiawerelowerthanthoseofthecontrolgroup(P<0.05).Thescoresoflactationandpostpartum2dlactationweresignificantlyhigherintheobservationgroupthaninthecontrolgroup(P<0.05).Conclusion:thelevelsofNO,NOS,FIB,D-dimerand2hbleedinginpatientswithpostpartumhemorrhageweresignificantlylowerthanthoseinpatientswithpostpartumhemorrhage.Durationanddurationoflochia,improvethetimeoflactation,improvethe1dlactationscoreandpostpartum2dlactationscore.keywordsPentoprostin;Cobiaoxytocin;NO;FIB;D-dimer;NOS;cesareansectionpostpartumhemorrhageChineseLibraryClassification(CLC):R714.62Documentcode:AArticleID:产后出血是产妇死亡的重要因素[1]。引起产妇出血的原因有：（1）产妇过于紧张的精神状况，引起子宫收缩力变差，导致产后出血；（2）胎盘滞留，包括胎盘剥落不全，胎盘粘连等；（3）凝血功能障碍，产妇有血液病、肝炎等要高度高危因素[2]。因此，须做好产前检查，...
