精品文档---下载后可任意编辑ALK 基因重排在儿童肺外 IMT 的表达及临床意义的开题报告摘要：儿童肺外间质性肺病（IMT）是儿童罕见的弥漫性间质性肺病，病因不明。本讨论旨在探讨 ALK 基因重排在儿童肺外 IMT 中的表达及其临床意义。共收集了 50 例确诊为儿童肺外 IMT 的患者样本，利用荧光原位杂交（FISH）技术检测 ALK 基因重排情况。同时，分析 ALK 重排与患者临床病理特征、治疗反应等相关性。结果显示，14 例患者（28%）存在ALK 基因重排，表明 ALK 基因重排可能是儿童肺外 IMT 的一个重要分子机制。ALK 重排阳性组中，患者年龄、原发病灶大小、多发性病变比例等临床特征与阴性组相比无明显差异。但 ALK 重排阳性组治疗效果更好，有望成为该疾病的治疗靶点。本讨论结果提示，ALK 基因重排是儿童肺外 IMT 的一个潜在分子机制，有望为该疾病的精准治疗带来新突破。关键词：儿童肺外 IMT；ALK 基因重排；FISH；治疗策略Abstract:Inflammatory myofibroblastic tumor (IMT) is a rare diffuse interstitial lung disease in children with unknown etiology. The purpose of this study is to investigate the expression and clinical significance of ALK gene rearrangement in pediatric extra-pulmonary IMT. A total of 50 pediatric extra-pulmonary IMT samples were collected and ALK gene rearrangement was detected by fluorescence in situ hybridization (FISH) technique. At the same time, the correlation between ALK rearrangement and clinical pathological features, treatment response was analyzed. The results showed that ALK gene rearrangement was detected in 14 patients (28%), indicating that ALK gene rearrangement may be an important molecular mechanism of pediatric extra-pulmonary IMT. There was no significant difference in clinical features such as patient age, primary lesion size, and multiple lesions proportion between ALK positive and negative groups. However, the positive group had better treatment results and is expected to become a therapeutic target for this disease. The results of this study suggest that ALK gene rearrangement is a potential molecular mechanism of pediatric extra-pulmonary IMT and may bring new breakthroughs to its precision treatment.精品文档---下载后可任意编辑Keywords: pediatric extra-pulmonary IMT; ALK gene rearrangement; FISH; treatment strategy.
