精品文档---下载后可任意编辑Atlastin 介导内质网同源膜融合的分子机制开题报告摘要：内质网 (ER) 是细胞内一个非常重要的细胞器，它参加了很多细胞的重要代谢和信号转导过程。ER 可以分为粗面和光面两部分，其中粗面 ER 与细胞质中的 mRNA、蛋白质合成和核糖体等有密切联系。ER 内部具有一定的等级结构，其内部膜的形态和结构决定了 ER 机能的实现和调节。在 ER 内部膜的形成和维持过程中，Atlastin 作为重要的介导蛋白参加了 ER 内部膜和同源膜的融合。本文将介绍 Atlastin 介导 ER 膜融合的分子机制和其对细胞的功能影响。关键词：内质网；Atlastin；膜融合；分子机制；功能影响Abstract:Endoplasmic reticulum (ER) is an important organelle in the cell, which participates in many important metabolic and signal transduction processes. ER can be divided into rough and smooth ER, among which rough ER has close relationship with mRNA, protein synthesis and ribosomes in the cytoplasm. ER has a certain hierarchical structure inside, and the morphology and structure of the internal membrane of ER determine the realization and regulation of its function. In the process of formation and maintenance of ER internal membrane, Atlastin, as an important mediating protein, participates in the fusion of ER internal membrane and homologous membrane. This article will introduce the molecular mechanism of Atlastin mediating ER membrane fusion and its functional impact on cells.Keywords: endoplasmic reticulum; Atlastin; membrane fusion; molecular mechanism; functional impact
