精品文档---下载后可任意编辑Cox-2、P53 在骨肉瘤中的表达及临床意义的开题报告摘要：骨肉瘤是一种恶性肿瘤，治疗困难，预后不良。本讨论旨在探讨 COX-2 和 P53 在骨肉瘤中的表达及其与预后的关系。通过检测骨肉瘤患者组织中 COX-2 和 P53 的表达水平，分析 COX-2 和 P53 的表达与患者预后的相关性。结果显示，COX-2 和 P53 的表达水平显著高于正常组织，COX-2 的高表达与预后差相关，P53 的高表达与预后无显著相关性。本讨论认为 COX-2 是一个重要的预后指标，可能成为治疗骨肉瘤的新靶点。关键词：骨肉瘤；COX-2；P53；表达；预后Abstract:Osteosarcoma is a malignant tumor with difficult treatment and poor prognosis. The purpose of this study is to explore the expression of COX-2 and P53 in osteosarcoma and their relationship with prognosis. By detecting the expression levels of COX-2 and P53 in the tissues of osteosarcoma patients, the correlation between the expression of COX-2 and P53 and the prognosis of patients was analyzed. The results showed that the expression levels of COX-2 and P53 were significantly higher than those in normal tissues, and the high expression of COX-2 was associated with poor prognosis, while the high expression of P53 was not significantly correlated with prognosis. In conclusion, COX-2 is an important prognostic indicator and may become a new target for the treatment of osteosarcoma.Keywords: Osteosarcoma; COX-2; P53; expression; prognosis
