精品文档---下载后可任意编辑LepR 基因缺陷与外源雌激素刺激导致小鼠成年后生殖障碍的讨论中期报告摘要：近年来，生殖障碍问题日益引起公众关注。雌激素是生殖功能调控的关键分子，对于小鼠的生殖发育有着重要的影响。在本讨论中，我们使用了 LepR 基因缺陷小鼠模型，探讨了外源雌激素刺激和基因缺陷对小鼠成年后生殖功能的影响。讨论发现，LepR 基因缺陷小鼠雌性和雄性均存在睾酮和孕酮减少的情况，但只有雌性小鼠出现了生殖障碍的现象。外源雌激素刺激后，雌性小鼠出现了更明显的生殖障碍。本讨论表明，LepR 基因缺陷对小鼠成年后生殖功能有着不可忽视的影响，并且外源雌激素对于生殖功能的调控可能存在复杂性。关键词：LepR 基因缺陷；生殖障碍；外源雌激素；小鼠；生殖功能。Abstract:In recent years, the problem of reproductive disorders has attracted increasing public attention. Estrogen is a key molecule in the regulation of reproductive function and has an important effect on the reproductive development of mice. In this study, we used LepR gene-deficient mice to investigate the effects of exogenous estradiol stimulation and gene defects on the reproductive function of adult mice. The results showed that both male and female LepR gene-deficient mice had reduced levels of testosterone and progesterone, but only female mice showed reproductive disorders. After exogenous estradiol stimulation, female mice showed more obvious reproductive disorders. This study suggests that LepR gene defects have a significant impact on the reproductive function of adult mice, and the regulation of reproductive function by exogenous estrogen may be complex.Keywords:LepR gene defect; reproductive disorder; exogenous estrogen; mice; reproductive function.
