精品文档---下载后可任意编辑microRNA-17 抑制人包皮成纤维细胞衰老的作用及机制讨论中期报告摘要：本文讨论了 microRNA-17 (miR-17)在人包皮成纤维细胞中的表达水平及其在细胞衰老中的作用和机制。通过文献讨论和实验验证，发现miR-17 表达水平在包皮成纤维细胞衰老过程中逐渐下调。进一步实验发现，miR-17 过表达能够促进包皮成纤维细胞的增殖和抗衰老，而 miR-17 的沉默则会导致细胞老化和凋亡。此外，miR-17 在调节包皮成纤维细胞衰老中可能通过下调 p21 和 p16 表达来实现。讨论说明，miR-17 可能是一个重要的调节因子，参加了包皮成纤维细胞衰老的调控。未来还需进一步讨论其相关分子机制，从而为包皮病的治疗提供新的靶点和方法。Abstract:This study investigated the expression level of microRNA-17 (miR-17) and its role and mechanism in cell senescence in human foreskin fibroblasts. Based on literature research and experimental verification, it was found that the expression level of miR-17 gradually decreased during the senescence of foreskin fibroblasts. Further experiments showed that miR-17 overexpression could promote cell proliferation and anti-aging of foreskin fibroblasts, while miR-17 silence could lead to cell aging and apoptosis. In addition, miR-17 may regulate the senescence of foreskin fibroblasts by down-regulating the expression of p21 and p16.This study suggests that miR-17 may be an important regulatory factor involved in the regulation of foreskin fibroblast senescence. Further research is needed to explore its related molecular mechanism, so as to provide new targets and methods for the treatment of foreskin diseases.
