精品文档---下载后可任意编辑乌司他丁对非体外循环冠脉搭桥术患者的心肌保护作用的临床讨论的开题报告【摘要】本次讨论旨在探讨乌司他丁对非体外循环冠脉搭桥术(Off-Pump Coronary Artery Bypass, OPCAB)患者的心肌保护作用。采纳随机对比实验的方法,在符合纳入和排除标准的患者中,将分为乌司他丁组和对比组,对两组患者的术前、术后 1h、12h 和 24h 进行心肌酶学指标、ECG 变化、血流动力学指标等方面的监测和比较。结果显示乌司他丁组患者心肌酶学指标上升幅度较对比组略微降低,血流动力学指标较对比组更为平稳,ECG 变化相对较小。表明乌司他丁可在一定程度上对非体外循环冠脉搭桥术患者的心肌进行保护,降低其手术后的心脏损害。【关键词】乌司他丁,非体外循环冠脉搭桥术,心肌保护,心肌酶学指标,ECG 变化,血流动力学指标【Abstract】The purpose of this study is to investigate the myocardial protective effect of ustiloxin on Off-Pump Coronary Artery Bypass (OPCAB) patients. Using a randomized controlled experiment method, patients who meet inclusion and exclusion criteria will be divided into the ustiloxin group and the control group, and the myocardial enzyme, ECG changes, hemodynamic indicators and other aspects of the two groups of patients will be monitored and compared before surgery, 1 hour, 12 hours, and 24 hours after surgery. The results showed that the degree of myocardial enzyme elevation in the ustiloxin group was slightly lower than that in the control group, and the hemodynamic indicators were more stable than those in the control group. ECG changes were relatively small. It indicates that ustiloxin can protect the myocardium of patients undergoing Off-Pump Coronary Artery Bypass to a certain extent and reduce their postoperative cardiac damage.【Key Words】ustiloxin, Off-Pump Coronary Artery Bypass, myocardial protection, myocardial enzyme, ECG changes, hemodynamic indicators