精品文档---下载后可任意编辑信号传导与转录激活因子 3 在涎腺腺样囊性癌和黏液表皮样癌中的表达及意义的开题报告摘要：涎腺腺样囊性癌和黏液表皮样癌是罕见的涎腺肿瘤，其病因和发病机制尚不清楚。本文旨在讨论信号传导与转录激活因子 3（STAT3）在这两种肿瘤中的表达及其相关意义。通过文献调研和实验验证，发现STAT3 在涎腺腺样囊性癌和黏液表皮样癌中高度表达，与肿瘤的侵袭性、转移能力、化疗敏感性等相关。此外，STAT3 还与多种信号通路相互作用，如 JAK/STAT、Wnt/β-catenin、PI3K/AKT 等，进一步增强肿瘤的恶性程度。因此，讨论 STAT3 在涎腺腺样囊性癌和黏液表皮样癌中的作用机制，为临床治疗提供新的靶点和方法。关键词：涎腺腺样囊性癌；黏液表皮样癌；STAT3；信号通路；治疗靶点Abstract:Salivary adenoid cystic carcinoma and mucoepidermoid carcinoma are rare salivary gland tumors, and the etiology and pathogenesis are still unclear. The purpose of this study is to investigate the expression and significance of signal transducer and activator of transcription 3 (STAT3) in these two types of tumors. Through literature research and experimental verification, it was found that STAT3 is highly expressed in salivary adenoid cystic carcinoma and mucoepidermoid carcinoma, and is related to the invasiveness, metastasis ability, chemotherapy sensitivity, etc. of the tumor. In addition, STAT3 also interacts with multiple signaling pathways, such as JAK/STAT, Wnt/β-catenin, PI3K/AKT, etc., further enhancing the malignancy of the tumor. Therefore, studying the role of STAT3 in salivary adenoid cystic carcinoma and mucoepidermoid carcinoma can provide new targets and methods for clinical treatment.Keywords: salivary adenoid cystic carcinoma; mucoepidermoid carcinoma; STAT3; signaling pathway; therapeutic target
