N-叔丁氧羰基哌嗪制备工艺研究

摘 要本文介绍了 N—叔丁氧羰基哌嗪，它是属于哌嗪类单取代化合物。此类药物与传统有机药物相比较具有高效的药理活性。在有机合成中，作为活泼的医药中间体,可进一步合成许多类型的有机化合物.具有很强的讨论意义。N-叔丁氧羰基哌嗪合成是由哌嗪出发，与冰醋酸发生成盐反应，无水乙醇作为溶剂，再加入二碳酸二叔丁酯通过酰化反应得到 N-叔丁氧羰基哌嗪粗品。在反应过程中需要严格控制 pH 值和温度，以此来减少副产物的生成。后处理中，以乙酸乙酯为萃取剂，除去未反应的原料与其他杂质.最后得到合格的 N—叔丁氧羰基哌嗪产品.经实验过程分析，实验数据验证。得出 N—叔丁氧羰基哌嗪的一些物化性质，可以看出此工艺具有一定的可行性，产品质量稳定，优于其它工艺路线。有着宽阔的市场效益和经济利润。关键词:N—叔丁氧羰基哌嗪； 哌嗪； 二碳酸二叔丁酯； 医药中间体；AbstractThis article describes the N-tert-butoxycarbonyl piperazine ， it belongs to a single substituted piperazine compounds 。 These drugs compared with traditional organic drugs with high pharmacological activity. In organic synthesis， as the active pharmaceutical intermediates, further synthesis of many types of organic compounds. Research has a strong meaning。 N-tert-butoxycarbonyl piperazine piperazine synthesized by starting with the acetic acid salt reaction occurs, anhydrous ethanol as solvent, then add the second di—tert-butyl carbonate obtained by acylation of N—tert—butoxycarbonyl piperazine crude 。 In the reaction process ， the need for strict control of pH value and temperature, in order to reduce the by—product formation 。 After treatment with ethyl acetate as extracting agent to remove unreacted raw materials， isomers and by—products and other impurities. Finally ， access to qualified N-Boc piperazine-based products. The experimental process analysis, experimental data 。 Obtained N—tert-butoxycarbonyl piperazine some of the physical and chemical properties, can be seen that th...