第1页共6页编号：时间：2021年x月x日书山有路勤为径，学海无涯苦作舟页码：第1页共6页非晶态雷尼镍论文：D-酒石酸修饰RaneyNi催化樟脑不对称加氢合成龙脑【中文摘要】手性化合物是一类重要的化合物,在香料、医药、农药和功能材料等方面具有广泛用途。开展手性合成的新方法和新催化剂的研究具有十分重要的意义。多相手性催化剂具有产物易分离,催化剂可以重复使用等优点,符合绿色化学发展方向。因此近年来开发和探索高效率、高光学选择性的的多相手性催化剂已成为手性催化研究的重要课题。采用具有光学活性的酒石酸修饰雷尼镍催化剂可以制得一种高效催化剂,该催化剂体系对羰基手性加氢具有良好的催化活性和对映体选择性。本课题将该催化体系用于催化天然樟脑不对称【英文摘要】Chiralcompoundsareimportantcompounds,whicharebroadlyusedinperfume,medicine,pesticide,functionalmaterialsandsoon.Ithasgreatimportancetoproducenewmethodandnewcatalystforchiralsynthesis.Therearetwokindschiralcatalyst,homogeneousandheterogeneousphasecatalyst.Homogeneousphasecatalysthashighreactionactivityandenantio-selectivity,butit’sexpensiveandhardtoreuse.Hetero-geneousphasecatalystsarefacile,easyoperatedandeasytoreused,whichareasgreen第2页共6页第1页共6页编号：时间：2021年x月x日书山有路勤为径，学海无涯苦作舟页码：第2页共6页chemicalcatalyst.Soitisimportantsubjecttodevelopnewcatalystwithhighreactionactivityandenantioselectivity.ThesystemofRaneyNimodifiedbyD-tartaricacidhighreactionactivityandenantio-selectivityoncarbonylcompoundshydrogenation.OursubjecttrystouseRaneyNi/D-TA/NaBrascatalystinhydrogenationofcomphor.Thisisthemainresearchcontents:(1)Findnewtechnicalroute.Byreadmanyabstract,wedecideourtechnicalrouteasthis:researchtheeffectsofD-tartaricacidconcentration,pHofmodifyingsolution,selectionofadditives,temperatureofmodificationandtimeofmodificationonRaneynickelcatalyst.Wefindoptimummodificationconditionsas:RaneyNi3g,modifiedin100mlsolutionwith1%D-tartaricacidconcentrationand2%NaBrconcentration,pH=4,whichareachievedbyadding1MNaOH,thenmodified1hourat100℃.(2)Theinfluenceofmostimportantfactorsontheopticalyieldandhydrogenationactivityvaryingthereactiontemperatureandpressure,solventtype,thereactiontimeandsoonweresystematicallyinvestigated.Bymanytests,Wefindoptimumconditionsasthis:comphor3g,modifiedRaneyNi3g,ethanol-第3页共6页第2页共6页编号：时间：2021年x月x日书山有路勤为径，学海无涯苦作舟页码：第3页共6页solution500ml,acetoacetate2g,stirringspeedas800r/min,reaction10hourat60℃.(3)Variousphysico-chemicalmethods,suchas,infra-redspectroscopy(FTIR),X-raydiffractometry(XRD),scanningelectronmicroscopy(SEM),BETsurfacearea,andsoon,wereemployedtogainadeeperunderstandingoftheinherentproblemofthefactorseffect.Asaresult,wefoundtheloadingamountofD-tartaricacidandcrystalstructurewarenearlysameafterhydrogenation,butRaneyNisurfacebecameirregular,nickelatomdissolved.(4)Toevaluatethemechanismofasymmetrichydrogenationofcomphor,weconsidermanyreferenceandourexperimentaldata,andputforwardchiralcatalyticmechanismofRaneyNi/D-TA/NaBrsystem.【关键词】非晶态雷尼镍D-酒石酸修饰不对称加氢樟脑【英文关键词】RaneynickelD-Tartaricacidmodificationasymmetrichydrogenationcomphor【目录】D-酒石酸修饰RaneyNi催化樟脑不对称加氢合成龙脑论文摘要8-10Abstract10-11第一章绪论12-251.1手性与手性合成技术12-141.1.1手性技术12-131.1.2.对映体组成的表示方法和测定方法13-141.2不对称催化加氢研究进展14-201.2.1多相不对称催化加氢研究进第4页共6页第3页共6页编号：时间：2021年x月x日书山有路勤为径，学海无涯苦作舟页码：第4页共6...
