3亿片/年贝诺酯片剂的生产车间的工艺设计摘要本毕业设计的目的是设计3亿片/年贝诺酯片剂的生产车间。在满足GMP要求的前提下，通过年生产任务推算出投料量，以此对提取工艺进行物料衡算，然后根据计算结果选择所需主要设备，同时也主要对非标准设备—振动筛分机进行了设计计算。在设备选型和非标设备计算完毕后，进行生产车间的平面和立面布置，确定出主要设备的平面立面位置。同时，为了达到GMP的标准，对生产管理、“三废”处理、消防卫生、劳动安全、环境保护等都设计了详细的实施制度。关键词：贝诺酯片剂，生产车间，设计ProcessDesignofProductionWorkshopaboutBenorilateTabletwithAnnualProductionCapacityof300millionABSTRACTThepurposeofthisgraduationprojectistodesignanannualoutputof300millionBenorilatetabletproductionworkshop.InthepremiseoftheGMPrequirement,throughtheyearofproduction,calculatethechargetovote,anddothematerialbalanceoftheproductionprocess,andthenselectthemainequipmentinaccordancewiththedesiredresults,alsodesigntheVibratingscreeningmachine.Afterthat,carryoutthedesignofthemainproductionworkshopanddeterminethelocationoftheequipments.Atthesametime,inordertoachieveGMPstandards,designdetailedimplementationofthesystemforproductionmanagement,"threewastes"treatment,firehealth,laborsafety,andenvironmentalprotection.KEYWORDS:Benorilatetablet,productionworkshop,design目录摘要.....................................................................IABSTRACT.................................................................II一、项目概述...........................................................11.1贝诺酯简介.........................................................11.1.1贝诺酯主要特点...............................................11.1.2药理作用......................................................21.1.3代动力学......................................................21.1.4适应症........................................................21.2片剂的特点.........................................................31.3原、辅料概述.......................................................51.4辅料的选择原则.....................................................61.5贝诺酯制剂车间的设计...............................................61.5.1设计的指导思想................................................61.5.2设计依据.....................................................61.5.3设计内容和重点...............................................71.5.4设计的目的和意义.............................................7二、生产工艺设计.......................................................72.1生产工艺流程.......................................................82.2贝诺酯片处方确定...................................................92.3生产安排及产品方案的确定...........................................92.3.1产品方案的确定................................................92.3.2生产时间安排.................................................10三、物料衡算.............................................................103.1物料衡算依据......................................................103.2物料衡算.........................................................103.2.1各原辅料每年有效需求量的计算...............................113.2.2各原辅料每年损耗量的计算...................................113.2.3物料消耗一览表.............................................12四、设备选型.............................................................124.1设备选型原则.......................................
