-549-不同重建算法对帕金森病相关脑功能网络的影响王元元1吴平1左传涛1张慧玮1葛璟洁1王坚2华逢春1赵军1管一晖1摘要目的：帕金森病相关脑功能网络（PDRP）是反映“皮质-纹状体-苍白球-丘脑-皮质”环路和相关解剖/功能通路葡萄糖代谢变化的影像学标志物。为推广其临床应用，需验证不同PET重建算法对PDRP表达值计算的影响。方法：将58例帕金森病(PD)患者及22例正常对照的18F-FDGPET显像图像分别进行滤波反投影法（FBP）及迭代法重建，基于华山医院PET中心建立的PDRP，应用SSM/PCA软件计算受检者经不同重建方法得到的PDRP表达值。结果：FBP法与迭代法PDRP表达值的差异无显著的统计学意义（PD组P>0.05；对照组P>0.05），两者呈显著正相关。PD组PDRP表达值显著高于对照组（FBP法：P<0.05；迭代法：P<0.05）。PDRP表达值与PD患者的UPDRS中的运动功能评分均呈显著正相关。结论：不同重建算法所得的PDRP表达值无显著统计学差异，不影响其在PD诊断及病情评估等中的临床效能，为PDRP在国内多中心的研究奠定了基础。关键词帕金森病；帕金森病脑代谢网络模式；18氟-脱氧葡萄糖；正电子发射断层扫描成像中图分类号：R445.6文献标志码：A文章编号：1006-5741(2013)-06-0549-04InfluenceofDifferentPETReconstructionAlgorithmsonParkinson’sDisease-relatedPatternExpressionWANGYuan-yuan1,WUPing1,ZUOChuan-tao1,ZHANGHui-wei1,GEJing-jie1,WANGJian2,HUAFeng-chun1,ZHAOJun1,GUANYi-hui1AbstractPurpose:Parkinson’sdisease-relatedpattern(PDRP)isanewlydiscoveredimagingbiomarker,whichcanreflecttheglucosemetabolicchangeof“Cortico-striato-pallidal-thalamo-cortical”loopandrelatedanatomical/functionalpathway.TheinfluenceofdifferentPETreconstructionalgorithmsonPDRPexpressionshouldbeverifiedbeforeitcanbewidelyusedintheclinic.Methods:The18F-FDGPETimagesof58Parkinson’sdisease(PD)patientsand22heathcontrolsubjects(HC)werereconstructedbyfilteredbackprojectionalgorithm(FBP)anditerativealgorithm(Iteration),separately.BasedonthePDRPfromPETcenter,HuashanHospital,thePDRPexpressionsofdifferentalgorithmswerecalculatedbySSM/PCAsoftware.Results:TherewasnodifferenceofPDRPexpressionbetweenFBPanditeration(PD:P>0.05;HC:P>0.05).TheyhadsignificantlypositivecorrelationwitheachotherbothinPDandHC(PD:P<0.05;HC:P<0.05).ThePDRPexpressionofPDgroupwassignificantlyhigherthanthatofHCgroup(FBP:P<0.05;Iteration:P<0.05).Inaddition,thePDRPexpressionhadsignificantlypositivecorrelationwithPDpatients'UPDRSmotorfunctionvalue(FBP:P<0.05;Iteration:P<0.05).Conclusion:ThePDRPexpressionfromdifferentreconstructionalgorithmshadnosignificantdifference.Additionally,thereconstructionalgorithmwillnotaffecttheapplicationofPDRPindiagnosisorassessmentofPD,whichisimportantfordomesticmulti-centerresearches.物理技术IMAGINGTECHNIQUE中国医学计算机成像杂志，2013，19：549-552作者单位：1复旦大学附属华山医院PET中心2复旦大学附属华山医院神经内科通信地址：上海市乌鲁木齐中路12号，上海200040通信作者：张慧玮(电子邮箱：eleanmailing@gmail.com)基金项目：国家自然科学基金（No.81171189）ChinComputMedImag,2013,19:549-5521PETCenter,HuashanHospital,FudanUniversity2DepartmentofNeurology,HuashanHospital,FudanUniversityAddress:12WulumuqiMiddleRd.,Shanghai200040,P.R.C.AddressCorrespondencetoZHANGHui-wei(E-mail:eleanmailing@gmail.com)Foundationitem:NationalNaturalScienceFoundation(No.81171189)中国医学计算机成像杂志2013年第19卷第6期ChinComputMedImag,2013,19(6)-550-帕金森病相关脑功能网络（Parkinson’sdisease-relatedpattern，PDRP）是新近发现的可以反映“皮质-纹状体-苍白球-丘脑-皮质”环路和相关解剖/功能通路葡萄糖代谢变化的影像学标志物[1]。PDRP是在对PD患者和正常对照者的脑18F-FDGPE...
