2015年7月第40卷第13期Vol.40，No．13July，2015·制剂与炮制·西洋参破壁饮片、粗粉与传统饮片中人参皂苷的体外溶出度比较徐浩淇1，2，陈莎2，章军2，杨世林1，成金乐3，彭丽华3，刘安2*(1.贵州大学药学院，贵州贵阳550025;2.中国中医科学院中药研究所，北京100700;3.国家中医药管理局中药破壁饮片技术与应用重点研究室，广东中山528473)［摘要］比较西洋参破壁饮片、粗粉与传统饮片中人参皂苷在水中和模拟胃液中溶出度，研究粉体粒径对西洋参溶出度的影响。采用高效液相色谱法测定西洋参破壁饮片、粗粉和传统饮片中5种人参皂苷成分在不同时间点的溶出量，绘制溶出曲线，比较不同形态西洋参皂苷成分的溶出特征。结果表明，在以水为溶出介质的实验中，西洋参破壁饮片中人参皂苷较粗粉、传统饮片具有更快的溶出速度，5min时溶出度就达到了总质量分数的90%，溶出量比饮片高出14%，比粗粉高出8%;在以模拟胃液为溶出介质的实验中，西洋参破壁饮片中人参皂苷比提取物中人参皂苷溶出速度上稍慢，但最大溶出量比传统饮片提取物高出5%，比粗粉高出14%。该文首次通过体外溶出度研究证明，西洋参破壁饮片化后能够改善其有效成分的溶出效率。［关键词］西洋参;破壁饮片;粗粉;传统饮片;溶出度;人参皂苷DissolutiondifferenceofginsenosidesfromultrafinegranularpowderandcommonpowdertraditionalpiecesofPanacisQuinquefoliiＲadixinvitroXUHao-qi1，2，CHENSha2，ZHANGJun2，YANGShi-lin1，CHENGJin-le3，PENGLi-hua3，LIUAn2*(1.CollegeofPharmacy，GuizhouUniversity，Guiyang550025，China;2.InstituteofChineseMateriaMedica，ChinaAcademyofChineseMedicalSciences，Beijing100700，China;3.KeyLaboratoryofUltrafineGranularPowderofHerbalMedicine，TechnologyandApplication，theStateAdiministrationofTraditionalChineseMedicine，Zhongshan528473，China)［Abstract］ThedissolutionofPanacisQuinquefoliiＲadixultrafinegranularpowderandcommonpowder，traditionalpiecesinwaterandsimulatedgastricjuiceinvitrowascompared，andtheeffectofparticlessizeofPanacisQuinquefoliiＲadixonthedissolutionwasstudied.HPLCmethodwasusedfordeterminationoffiveginsenosidesincludingＲg1，Ｒe，Ｒb1，ＲcandＲdfromultrafinegranularpowderandcommonpowder，traditionalpiecesofPanacisQuinquefoliiＲadixatdifferentpointsintime，furthermore，thedissolutioncurvesofPanacisQuinquefoliiＲadixultrafinegranularpowderandcommonpowder，traditionalpieceswereobtained.ThedissolutioncharacteristicsofthethreePanacisQuinquefoliiＲadixformswerealsocomparedinthisstudy.Accordingtotheresults，thedissolutionratesofginsenosidesfromultrafinegranularpowderexceeded90%ofthetotalcontentwith5min，significantlyhigherthanthatoftheothertwoformsinwaterinvitro.Atthesametime，thedissolvedamountoftheultrafinegranularpowderwasfourteenpercenthigherthanthatofthetraditionalpiecesandeightpercenthigherthanthatofthecommonpowder.Undertheconditionofsimulatedgastricjuiceinvitro，thedissolutionratesofginsenosidesfromultrafinegranularpowderwerelittlelowerthanthatoftheothertwo，butthemaximumdis-solvedamountoftheformerwasfourteenpercenthigherthanthatofthecommonpowderandfivepercenthigherthanthatoftheextracts.ThereforetheconclusionisthatmicronizationofPanacisQuinquefoliiＲadixcontributedtodissolutionofeffectivecomponents.［Keywords］PanacisQuinquefoliiＲadix;ultrafinegranularpowder;commonpowder;traditonalpieces;dissolutionrate;ginsenosidesdoi:10．4268/cjcmm20151317［收稿日期］2015-01-31［通信作者］*刘安，研究员，硕士生导师，主要从事中药化学研究，Tel:(010)64030267，E-mail:la62@163.com［作者简介］徐浩淇，硕士研究生，Tel:(010)64030267，E-mail:xhq880920@163.com·6752·徐浩淇等:西洋参破壁饮片、粗粉与传统饮...
