干细胞与视神经保护及其损伤修复_英文_VIP免费

中国组织工程研究与临床康复第14卷第23期2010–06–04出版JournalofClinicalRehabilitativeTissueEngineeringResearchJune4,2010Vol.14,No.23ISSN1673-8225CN21-1539/RCODEN:ZLKHAH4367StateKeyLaboratoryofOphthalmology,ZhongshanOphthalmicCenter,SunYat-senUniversity,Guangzhou510060,GuangdongProvince,ChinaZhangMin★,Studyingformaster’sdegree,StateKeyLaboratoryofOphthalmology,ZhongshanOphthalmicCenter,SunYat-senUniversity,Guangzhou510060,GuangdongProvince,Chinazhangm35@mail2.sysu.edu.cnCorrespondenceto:HuangBing,Master,Associateinvestigator,StateKeyLaboratoryofOphthalmology,ZhongshanOphthalmicCenter,SunYat-senUniversity,Guangzhou510060,GuangdongProvince,Chinahuangbing2000@hotmail.comSupportedby:ScienceandTechnologyPlanProjectofGuangdongProvince,No.2008A060202008*Received:2010-01-06Accepted:2010-02-06(20091106011/ZS)ZhangM,HuangB.Stemcellsinopticnerveprotectionandrestorationfollowinginjury.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu.2010;14(23):4367-4370.[http://www.crter.cnhttp://en.zglckf.com]Stemcellsinopticnerveprotectionandrestorationfollowinginjury*★◆ZhangMin,HuangBingAbstractBACKGROUND:Asaspeciallydifferentiatedcentralnerve,opticnerveisonceinjured,retinalneuronsarehardtorestoreandregenerate.Asaresult,visualfunctionislostpermanently.Currently,aneffectiveclinicaltreatmentisnotavailable.Duetothemulti-directionaldifferentiatedpotentialofstemcells,theirroleinopticnerveprotectionandrestorationfollowinginjuryisbecomingahotresearchspot.OBJECTIVE:Toreviewtheclassificationandtransplantationofstemcellsinopticnerveprotectionstudy,aswellasrolesofstemcellstransplantationinopticnerveprotectionandrepairfollowinginjury.METHODS:ThedatabaseofISIWebofKnowledgeplatformwassearchedoncomputerfromFebruary1994toApril2009,withthekeywords“stemcells,opticnerve”inEnglish.Inthesameway,thedatabaseofCNKIfromFebruary1994toApril2009wasalsoscreened,withthekeywords“stemcells,opticnerve”inChinese.RESULTSANDCONCLUSION:Atotalof98literaturesrelatedtostemcellsinopticnerveprotectionandrestorationafterinjuryarecollected,inwhich23papersareChineseand75papersareEnglish.Thestudiespublishedearlier,repetitivelyandsimilarlyareremoved,and38paperswhichcomplywiththestandardsareinvolvedintothisreview.Stemcellsownthepotentialofself-renewphysiologically,aswellaspotentialofrepairingtheinjuries.Atpresent,mostoftheresearchesonstemcellsinopticnerveprotectionandrestorationafterinjuryarerepresentedinmorphosis.Howtoimplantstemcellssafelyandeffectivelyandhowtorecoverstablevisualfunctionstillneedourefforts.Stemcellsderivedfromskin,peripheralblood,fatandothertissuesareconvenienttodrawmaterialsandarecommendablesubjects,weshouldstudythemdeeplytomakepreferableuse.INTRODUCTIONGlaucoma,age-relatedmaculardegeneration,trauma-orischemia-causedopticneuropathyarethecurrentmaincausesofblindness.Successfultreatmentofopticnervediseasesaredividedintothreesteps:①Topreventretinalganglioncelldeath.②Toinducetheretinalganglioncelldegenerationandaxonalregeneration.③Toestablishthesynapticrelationshipsbetweenretinalganglioncellsandtargettissues.Step1,topreventretinalganglioncelldeath,isknownastheneurologicalprotection,Step2andStep3torestorenervefunction,servingasnerverepair[1].Thecurrenttreatmentforthesediseasesisbasedonthepremisethatwipingoutthemaincause,topreventtheretinalnervecell’sapoptosisordeathbyusingtheappropriatedrugsaccordingtovariedreasonsands...