2010年7月第7卷第l9期·药物与临床·埃索美拉唑与奥美拉唑治疗胃溃疡临床疗效比较吴海雄(广东省河源市连平县第二人民医院,广东连平517139)f摘要】目的:观察埃索美拉唑或奥美拉唑、阿莫西林、克林霉素三联疗法治疗胃溃疡的临床疗效。方法:将60例经胃镜确诊为胃溃疡的患者随机分为实验组和对照组,每组各30例。实验组给予埃索美拉唑20m阿莫西林1g、克林霉素500mg,而对照组给予奥美拉唑20mg、阿莫西林1克拉霉素500mg,疗程共7d。评估两组患者在治疗前和治疗7d后的临床症状、胃黏膜溃疡改善情况、Hp根除率以及用药后的不良反应。结果:实验组和对照组症状改善率分别为85.1%和80.0%,Hp根除率分别为93.2%和84.6%,胃黏膜溃疡改善率为90.7%和84.2%,两组比较,差异均有统计学意义(P<0.05),两组不良反应发生率相似。结论:埃索美拉唑三联疗法治疗胃溃疡的疗效优于奥美拉唑三联疗法.值得本地区临床推广。『关键词】胃溃疡;质子泵抑制剂;幽门螺杆茵【中图分类号】R573。1【文献标识码】B【文章编号】1673—7210(2010)07(a卜073—03ClinicaleficiencycomparisonofEsomeprazoleandOmeprazoletriplethera-plesongastriculcerHa/x/ongfheSecondPeoplesHospitalofLianpingCounty,HeyuanCity,GuangdongProvince,Lianping517139,China)【Abstract]Objective:ToevaluatetheclinicalefficiencyofEsomeprazoleorOmeprazole,AmoxicillinandClindamycintripletherapiesongastriculcer.Methods:Werandomlyseparated60patientswhohadbeenapprovedgastriculcerbygastricendoscopeintoexperimentalgroup(,30)andcontrolgroup(,3o).ExperimentalgrouppatientstreatedbyEsomepra-zole20mg,Amoxicillin1gandClindamycin500mgperdaywhereascontrolgrouptreatedbyOmeprazole20mg,Amoxi—cillin1gandClindamycin500mgperdayfortotally7days.Be~retreatmentand7daysaftertreatment,clinicalsymp—tom,conditionimprovementofstomachmucous,eliminatedrateofHpandthesideefectofdrugwerecomparedbetweenthetwogroups.Results:Thesymptomimprovementrateinexperimentalgroupandcontrolgroupwere85.1%and80.0%respectively,theeliminatedrateofHpwere93.2%and84.6%,andtheulcerconditionimprovementrateinbothgroupswere90.7%and84.2%,thediferencesbetweentwogroupwerestatisticalsignificance(P