2010年7月第7卷第l9期·药物与临床·埃索美拉唑与奥美拉唑治疗胃溃疡临床疗效比较吴海雄(广东省河源市连平县第二人民医院，广东连平517139)f摘要】目的：观察埃索美拉唑或奥美拉唑、阿莫西林、克林霉素三联疗法治疗胃溃疡的临床疗效。方法：将60例经胃镜确诊为胃溃疡的患者随机分为实验组和对照组，每组各30例。实验组给予埃索美拉唑20m阿莫西林1g、克林霉素500mg，而对照组给予奥美拉唑20mg、阿莫西林1克拉霉素500mg，疗程共7d。评估两组患者在治疗前和治疗7d后的临床症状、胃黏膜溃疡改善情况、Hp根除率以及用药后的不良反应。结果：实验组和对照组症状改善率分别为85．1％和80．0％，Hp根除率分别为93．2％和84．6％，胃黏膜溃疡改善率为90．7％和84．2％，两组比较，差异均有统计学意义(P<0．05)，两组不良反应发生率相似。结论：埃索美拉唑三联疗法治疗胃溃疡的疗效优于奥美拉唑三联疗法．值得本地区临床推广。『关键词】胃溃疡；质子泵抑制剂；幽门螺杆茵【中图分类号】R573。1【文献标识码】B【文章编号】1673—7210(2010)07(a卜073—03ClinicaleficiencycomparisonofEsomeprazoleandOmeprazoletriplethera-plesongastriculcerHa／x／ongfheSecondPeoplesHospitalofLianpingCounty，HeyuanCity，GuangdongProvince，Lianping517139，China)【Abstract]Objective：ToevaluatetheclinicalefficiencyofEsomeprazoleorOmeprazole，AmoxicillinandClindamycintripletherapiesongastriculcer．Methods：Werandomlyseparated60patientswhohadbeenapprovedgastriculcerbygastricendoscopeintoexperimentalgroup(，30)andcontrolgroup(，3o)．ExperimentalgrouppatientstreatedbyEsomepra-zole20mg，Amoxicillin1gandClindamycin500mgperdaywhereascontrolgrouptreatedbyOmeprazole20mg,Amoxi—cillin1gandClindamycin500mgperdayfortotally7days．Be~retreatmentand7daysaftertreatment，clinicalsymp—tom，conditionimprovementofstomachmucous，eliminatedrateofHpandthesideefectofdrugwerecomparedbetweenthetwogroups．Results：Thesymptomimprovementrateinexperimentalgroupandcontrolgroupwere85．1％and80．0％respectively，theeliminatedrateofHpwere93．2％and84．6％，andtheulcerconditionimprovementrateinbothgroupswere90．7％and84．2％，thediferencesbetweentwogroupwerestatisticalsignificance(P
