·30·口腔颌面外科杂志2011年2月第21卷第1期JournalofOralandMaxillofacialSurgeryVol21No．1February，2011阿霉素神经干注射结合病变骨腔外科处理治疗原发性三又神经痛的临床观察雷荣昌，梁非照，王俊林(广西医科大学第五附属医院口腔科，广西柳州545006)【摘要】目的：对阿霉素神经干注射结合骨腔外科处理治疗原发性三叉神经痛的临床疗效进行评估，了解其临床应用价值方法：60例原发性三叉神经痛患者随机分为2组．治疗组以阿霉素行三叉神经干注射结合病变骨腔外科处理进行治疗，对照组口服卡马西平。对两组疼痛评分及临床疗效进行分析，并进行统计学处理结果：治疗1年后随访，治疗组29例，对照组28例，随访率>90％。治疗组患者的疼痛评分为(2．38~1．90)，对照组患者的疼痛评分为(4．07~2．00)，两组数据间比较，有统计学意义ft=-3．28，P<0．o1)治疗组的总有效率为93．1％，对照组的总有效率为75．O％，治疗组优于对照组()(z=l1．99，P<0．01)。结论：阿霉素神经干注射结合病变骨腔外科处理治疗原发性三叉神经痛疗效确切、简便易行【关键词1阿霉素；神经干注射；外科处理；原发性三叉神经痛【中图分类号】R745．11【文献标志码]A[文章编号11005—4979(2011)01—0030—04doi：10．39694．issn．1005—4979．2011．01．008ClinicalObservationofAdriamycinNerve-trunkInjectionCombiningwithSurgicalManagementofPathologicalBoneCavityinTreatingPrimaryTrigeminalNeuralgiaLEIRong-chang,LIANGFei—zhao，WANGJun—lin(DepartmentofStomatology，theFifthAffiliatedHospitalofGuangxiMedicalUniversity,Liuzhou545006,GuangxiZhuangMinorityAutonomousRegion，China)[Abstract】Objective：Toevaluatetheclinicaleffectsofadriamycinnerve·trunkinjectioncombinedwithsurgicalmanagementofpathologicalbonecavityintreatingprimarytrigeminalneuralgia．Methods：60patientswithprimarytrigeminalneuralgiawererandomlydividedintotwogroups：thetreatmentgroupandcontrolgroup．Thepatientsintreatmentgroupacceptedadriamycinnerve—trunkinjectioncombinedwithsurgicalmanagementofpathologicalbonecavity．Thepatientsincontrolgroupweretreatedwithcarbamazepine．1yearaftertreatment，thepatientswerefollowedup．Thepainscoreandclinicaleficacywerecomparedandanalyzedstatisticallybetweenthetwogroups．Results：29peoplewerefollowedupinthetreatnlentgroup；28peoplewerefollowedupinthecontrolgroup．Therateoftollow—upwasmorethan90％．Thepainscoreofpatientsintreatmentgroupwas2．38+1．90．and4．07±2．O0inthecontrolgroup．Therewassignificantdifferencebetweentwogroups(t=-3．28，P<0．O1)．Thetotaleffectiverateintreatmentgroupwas93．10％，75％inthecontrolgroup．Therewassignificantdifferencebetweenthetwogroups(X=11．99，P<0．01)．Conclusion：Adriamycinnerve—trunkinjectioncombinedwithsurgicalmanagementofpathologicalbonecavityisasimpleandeffectivetherapeuticmethodintreatmentofprimarytrigeminalneuralgia．【Keywords】Adriamycin；nerve—trunkinjection；pathologicalbonecavity；primarytrigeminalneuralgia原发性三叉神经痛(primarytrigeminalneuralgia．PTN)是一种好发于中老年人的常见病．表现为面部某一区域内出现阵发性的电击样疼痛．严重影响患收稿日期：基金项目：作者简介：通信作者：2010．10。06柳州市科技局资助项目(2008031426)雷荣昌(1967．)，男，湖南沅江人，副主任医师，博士雷荣吕．副主任医师．E．mail：Leroch@tom．eom者的生活其病因和发病机制尚不明确【l_在临床工作中．三叉神经痛的治疗方法多种多样．但疗效参差不齐。为寻找一种安全、有效、操作简便的治疗方法，我科于2006-2010年采用阿霉素神经干注射结合病变骨腔外科处理治疗原发性三叉神经痛患者．并与口服卡马西平治疗的患者进行了比较．现报告如下雷荣昌．等．阿霉素神经于注射结合病变骨腔外科处理治疗原发性三叉神经痛的临床观察LEIR...
