IntJOphthalmol，Vo1．11，No．12，Dec．2011www．IJO．caTel：029-8224517283085628Email：IJO．2000@163．com·临床论著·长期联合应用噻吗洛尔对结膜组织炎性反应的影响彭坤，许银霞，王保君，杨玉新基金项目：中国新乡市科技局资助项目(No．08S022)作者单位：。(453100)中国河南省卫辉市，新乡医学院第一附属医院眼科；(472000)中国河南省三门峡市中心医院眼科作者简介：彭坤，男，硕士，讲师，主治医师，研究方向：玻璃体视网膜疾病。通讯作者：彭坤．pengkun73@163．corn收稿日期：2011—08—31修回日期：2011—10—10ConjunctivainflammatorychangesinducedbylongtimeandcombinedtreatmentwithtimololKunPeng，Yin．XiaXu，Bao．JunWang，Yu-XinYangFoundationitem：XinxJangMunicipalScienceandTechnologyAgency—fundedProject，China(No．08S022)DepartmentofOphthahnology，theFirstAffiliatedHospitalofXinxiangMedicalUniversity，Weihui453100，HenanProvince，China；DepartmentofOphthalmology，SanmenxiaCentralHospital，Sanmenxia472000，HenanProvince，ChinaC0rrespOndenceto：KunPeng．DepartmentofOphthalmology，theFirstAffiliatedHospitalofXinxiangMedicalUniversity．Weihui453100．HenanProvince．．China．pengkun73@163．cornReceived：2011—08—31Accepted：2011—10—10Abstract·AlM：ToobserveconiunctivaIinflammatoryreactionandexpressionofinfIammatOrvmarkerICAM一1afterlongtimetreatmentwithanti—glaucomaeyedrops，andtoinvestigatetheimpactonconjunctiva．·METHODS：Ninetyprimaryopen—angleglaucomapatientswerecollected．Allpatientsweredividedintothreegroupsinaccordancewiththetypeoftreatmentbyusingtheanti—glaucomadrug：combinedmedicationgroupof30cases，singledrugtreatmentgroupof30cases；non—druggroupof30cases．30caseswithsimplecataractactedasblankcontrolgroup．Eachgroupwasdividedinto3timephrase(0-6，7—12，13—18months)sub—groupsbyanti—glaucomadrugtreatmenttimeandcataractsicktime．toconductopticalmicroscopyobservationonconjunctivalepithelialhistomorphologyanddetectICAM一1expression．·RESULTS：Singledrugtreatmentgroupinapplyingdrugsfor13—18monthshadobviousbuIbarconjunctivaIhistologychangesfeaturedbyitsbulbarconjunctivalepithelialtissuethickening，irregularshape，macrophages，lymphocytes，fibroblastsincreaseandirregularsubconjunctivalfibrousconnectivetissue．Combinedmedicationgroupinapplyingdrugsfor13—18monthshadobviousbulbarconjunctivalhistologychangesfeaturedbythebulbarconjunctivaltissuewithvaryingdegreesofepithelialhyperplasiaormetaplasia，unevenepithelialthickness，increasednumberofsmallbloodvesselsinsubconjunctivaltissue，andmacr0phages，lymphocytes，fibroblastsmarkedlyincreased．gobletcellsdecreased．Inthe13—18monthstimephrase，singledrugtreatmentgroupandcombinedmedicationgroup，comparedwiththeothergroupsinICAM一1positivecellnumberofconjunctivalepithelialtissue，hadstatisticallysignificantdiferences(尸<0．01)．·CONCLUSlON：TheconjunctivaltissueinflammatorvresponseandconjunctivalepithelialtissuesinflammatorymarkerICAM一1expressionincreasedsignificantly．·KEYWORDS：timolol；infIammatorymarker；glaucoma；conjunctivaPengK，XuYX，WangBJ，eta1．Conjunctivainflammatorychangesinducedbylongtimeandcombinedtreatmentwithtimolo1．YankeZazhiIntJOphthMmol2011；11(12)：2099—2101摘要目的：通过观察长期应用抗青光眼滴眼剂作用后结膜炎症反应的发生和炎性标记物ICAM一1在眼部的表达，探讨长期应用抗青光眼滴眼剂对结膜反应的影响。方法：从我科收住的原发性开角型青光眼患者90例，分为三组：应用5g／L噻吗洛尔与2g／L阿法根(联合用药组)30例；应用5g／L噻吗洛尔(单一...
