中国临床保健杂志2011年2月第l4卷第1期ChinJClinHeahhc,February201l,Vo1.14,NO.1糖尿病患者亚临床型甲状腺功能减退症患病情况郑海兰,任安,叶山东,郑茂,王亚虹(安徽医科大学附属省立医院、安徽省立医院内分泌科,合肥230001)·47··论著·[}商要]目的了解住院糖尿病患者亚临床甲减患病情况。方法318例住院糖尿病患者为病例组,对照组为62例血糖正常的健康体检者,年龄、性别比与病例组相似。采用化学发光法检测甲状腺功能,其中134名糖尿病患者同时测定了甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素受体抗体(TRAb)。结果(1)糖尿病合并甲状腺功能异常发生率为21.4%,其中亚临床型甲减发生率13.8%,显著高于正常人群,分别为8.06%和4.84%(P<0.05);(2)随糖尿病病程的延长,亚临床型甲减发生率增加(P<0.05);糖化血红蛋白(HbA。C)≤9%的患者亚临床型甲减发生率显著高于HbA。c>9%的患者(P<0.05);TPOAb、TGAb阳性患者亚临床甲减发生率高于TPOAb、TGAb阴性的糖尿病患者。结论糖尿病患者甲状腺功能异常发生率较高,主要表现为亚临床型甲状腺功能减退,其与糖尿病病程、血糖控制情况及甲状腺自身抗体有关。[关键词]糖尿病;甲状腺功能减退症;危险因素[中图分类号]R587.1[文献标识码]ADOI:10.3969/J.issn.1672-6790.2011.O1.016Analysisofsubcliulcalhypothyroidismindiabeticpafien~ZHENGHai-lan,PENAn,YEShan·dong,ZHENGMao,WANGYa—hong(DepartmentofEndocrinology,AnhuiProvincmlHospital,Hefei230001,China)Correspondingauthor:REⅣAn,E-mail:renAn@163.tom[Abstract]0bjectiveToevaluatetheincidenceofsubclinicalhypothyroidismindiabeticpatients.Methods318diabetichospitalizedpatientswereselectedintodiabetesgroup,nomalcontrolgroupinclude62healthypersonswithnormolbloodglucose.Serumthyroidfunctiontestsofallsubjectswereperformedandthethyroidantibodies(TPOAb,TGAb,TRAb)in134diabeticpatientsweredetectedbychemiluminescence.Results(1)Theincidenceofabnormalthyroidfunctionindiabeteswas21.4%,theprevalenceofsubclinicalhypothyroidismwas13.8%,whichbothweresignificantlyhigherthanthose(8.o6%and4.84%,respectively)inthenormalgroup(P<0.05).(2)Theincidenceofsubclinicalhypothyroidismsignificantlyincreasedwithincreasingdurationofdiabetes(P<0.05)andde-creasingHbA】C(P