TPH基因多态性与重性抑郁症及症状表型的相关性VIP免费

下载后可任意编辑TPH 基因多态性与重性抑郁症及症状表型的相关性【摘要】 目的 探讨中国汉族 TPH A218C 多态性与抑郁症及症状表型的相关性。方法 采纳 PCR RFLP方法讨论 70 例抑郁症(重性抑郁症)患者的 TPH 基因的多态性分布；采纳汉密尔顿抑郁量表(HAMD)评定症状表型。结果 抑郁症组 TPH A218C 多态性的等位基因 C 的频率(%)明显高于对比组(%)，而 A 等位基因的频率(%)和 A/A 基因型的频率(%)显着低于对比组(%和%)(χ2= ，P=)；(χ2=, P=)。按性别分层后，男性下载后可任意编辑抑郁症组 C/C 基因型的频率(%)明显高于对比组(%)，而 A/A 基因型的频率(%)显着低于对比组(%)(χ2=, P=)；病例组中症状表型在三种基因型间分布无显着性差异。结论 TPH A218C 基因的多态性与抑郁症发病相关，其相关性受性别影响，而与症状表型间无明显的关联。【关键词】 抑郁症；色氨酸羟化酶基因；多态性 Association of TPH gene polymorphism with major depression 下载后可任意编辑and symptom phenotypes ABSTRACT: Objective To explore the association among the depression, symptom phnotypes and polymorphism TPH A218C in the Han Chinese. Methods TPH A218C was determined using a PCR based technique. TPH was genotyped using restriction fragment length polymorphism in 70 patients affected by depression and 70 unrelated evaluated the symptom phenotypes of 下载后可任意编辑cases applying the Hamilton Rating Scale for depression(HAMD). Results The TPH A218C genotype distribution in 70 patients with major depression was significantly different from that in controls (χ2=, P=). The C allele in patients (%) was significantly more frequent than in controls (%) but the A allele (%) and A/A genotype (%) were significantly less frequent than in controls (% and %) (χ2=, 下载后可任意编辑P=). Meanwhile, among the males, a trend was observed toward an excess of TPH C/C (% vs. %) in patients and excess of TPH A/A in controls (% vs. %) (χ2=, P=). There were no significant diffe...