医学微生物学病毒单纯疱疹病毒VIP免费

10/20/24病原病理教研室1生物学性状单纯疱疹病毒致病性微生物学检查防治原则复习思考题10/20/24病原病理教研室2Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.疱疹病毒共同特性1、球形，核心为DNA，有包膜和刺突2、感染细胞后产生明显的CPE，核内出现嗜酸性包涵体3、感染人体后表现为增殖性感染和潜伏感染；可垂直传播影响子代4、引起人类疾病的疱疹病毒主要有：EB病毒、巨细胞病毒、单纯疱疹病毒、水痘-带状疱疹病毒等10/20/24病原病理教研室3Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.生物学性状1、HSV为球形有包膜DNA病毒2、血清型:HSV-1和HSV-23、可在多种细胞中增殖，核内出现嗜酸性包涵体10/20/24病原病理教研室4Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.致病性1、传染源——病人和带毒者2、传播途径——密切接触、性接触、飞沫3、临床表现：1）原发感染：HSV-1---唇疱疹、角膜结膜炎、脑炎、甲沟炎HSV-2---生殖器疱疹2）潜伏感染：HSV-1---三叉神经节、颈上神经节HSV-2---骶神经节增殖性感染10/20/24病原病理教研室5Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.单纯疱疹病毒引起的唇疱疹10/20/24病原病理教研室6Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.生殖器疱疹10/20/24病原病理教研室7Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.HSV-1可潜伏于三叉神经节10/20/24病原病理教研室8Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.微生物学检查1、采集标本接种于兔肾、人胚肾细胞，观察细胞病变2、免疫学检测10/20/24病原病理教研室9Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.防治原则1、无有效特异性预防疫苗2、治疗首选无环鸟苷3、孕妇产道感染HSV-2者，可行剖宫产或新生儿注射丙种球蛋白4、碘苷、阿糖胞苷对疱疹性角膜炎有较好疗效10/20/24病原病理教研室10Throughthispublicitycampaign,furtherimprovethesenseofbusinessintegrityoftourismenterprisestohelptourismconsumersandoperatorstosafeguardthelegitimaterightsandinterests,toensurethatourCity'stourismsustainable,healthyandcoordinatedDevelopment.复习思考题HSV-1在体内的潜伏部位是：A、疱疹复发部位的末梢神经细胞B、局部淋巴结C、口腔黏膜毛细血管内皮细胞D、三叉神经节