CT评估肺动脉高压与肺心病的临床价值CT评估肺动脉高压现况CT评估肺动脉高压目前研究CT评估肺动脉高压(PAH),主要集中于肺动脉内径(PAD)以及升主动脉与主肺动脉比值比(rPA)。而越来越多的研究也证明其他CT指标如左、右心室内径比值(RV/LV)、室壁厚度、室间隔厚度也具有评估价值。CT评估PAH现况1、TruongQA,MassaroJM,RogersIS,etal.Referencevaluesfornormalpulmonaryarterydimensionsbynoncontrastcardiaccomputedtomography:theFraminghamHeartStudy.[J].CirculationCardiovascularImaging,2012,5(1):147-54.2、CorsonN,LabbyZE,StrausC,etal.CT-basedpulmonaryarterymeasurementsfortheassessmentofpulmonaryhypertension[J].AcademicRadiology,2014,21(4):523-530.Truong等人报道,706名健康成人,CT测定PAD的正常值为男性≤29mm,女性≤27mm。CT评估PAH现况TruongQA,MassaroJM,RogersIS,etal.Referencevaluesfornormalpulmonaryarterydimensionsbynoncontrastcardiaccomputedtomography:theFraminghamHeartStudy.[J].CirculationCardiovascularImaging,2012,5(1):147-54.Chan等人报道,101例急诊肺动脉高压患者,以PAD≥29mm作为肺动脉高压的诊断标准,其敏感度为77.4%,特异度为89.6%。而右室壁厚度、RV/LV、肺动脉左右分支管径以及rPA均可以作为筛查肺动脉高压的参考指标。CT评估PAH现况ChanAL,JuarezMM,SheltonDK,etal.Novelcomputedtomographicchestmetricstodetectpulmonaryhypertension[J].BMCMedicalImaging,2011,11(1):7.Lange等人报道,以PAD≥29mm作为26例临界肺动脉高压的诊断标准,其敏感度为77%,特异度为62%。CT评估PAH现况LangeTJ,DorniaC,StiefelJ,etal.Increasedpulmonaryarterydiameteronchestcomputedtomographycanpredictborderlinepulmonaryhypertension[J].PulmonaryCirculation,2013,3(2):363-368.Corson等人报道,191例患者以rPA>1作为肺动脉高压的诊断标准,其敏感度、特异度分别为89%、82%。CT评估PAH现况CorsonN,LabbyZE,StrausC,etal.CT-basedpulmonaryarterymeasurementsfortheassessmentofpulmonaryhypertension[J].AcademicRadiology,2014,21(4):523-530.Condliffe等人报道,48例肺动脉高压患者以RV/LV>1作为肺动脉高压的诊断标准,其敏感度为80%,特异度为89%。相比于rPA,RV/LV能更好地预测生存率。CT评估PAH现况CondliffeR,RadonM,HurdmanJ,etal.CTpulmonaryangiographycombinedwithechocardiographyinsuspectedsystemicsclerosis-associatedpulmonaryarterialhypertension[J].Rheumatology,2011,50(8):1480.Condliffe等人还报道了CT-rPA分别联合超声下三尖瓣返流速度(TG)、RV/LV可以提高肺动脉高压筛查的准确率。CT/echocompositeindex=0.27×TG+29.355×rPA-9.031CTcompositeindex=38.968×rPA+8.589×RV/LV-16.057CT评估PAH现况CondliffeR,RadonM,HurdmanJ,etal.CTpulmonaryangiographycombinedwithechocardiographyinsuspectedsystemicsclerosis-associatedpulmonaryarterialhypertension[J].Rheumatology,2011,50(8):1480.CT目前也可以用于心功能及血流状态的评估。Pienn等人报道,23例肺动脉高压患者的对比剂流速及加速时间与对照组存在差异。Reve等人报道,心电门控CT测定的45例PAH患者,其心脏收缩期和舒张期时右肺动脉的横截面积会异常与常人CT由于容积效应、伪影以及造影剂不均匀分布等多种因素,导致CT下观察到的心脏结构多有误差。故相较于心脏MRI,CT很少在临床上用于心功能及血流状态评估。CT评估PAH现况1.PiennM,KovacsG,TschernerM,etal.Non-invasivedeterminationofpulmonaryhypertensionwithdynamiccontrast-enhancedcomputedtomography:apilotstudy.[J].EuropeanRadiology,2014,24(3):668.2.RevelMP,FaivreJB,Remy-JardinM,etal.Pulmonaryhypertension:ECG-gated64-sectionCTangiographicevaluationofnewfunctionalparametersasdiagnosticcriteria[J].Radiology,2009,250(2):558-566.现本组meta分析CT评估肺动脉高压检索数据库:PubMed,Embase,WebofScience。检索...