早产儿代谢性骨病的研究进展 早产儿代谢性骨病是由于早产儿先天性体内钙、磷等矿物质储藏局限性,生后肠外营养等因素而影响钙、磷吸取造成骨代谢异常,出现骨矿含量减少,骨密度减少。该病可影响患儿生长乃至成年后骨骼健康,明显影响学龄期的身高,还可能是造成其晚年易发生骨质疏松症的因素之一。其诊疗重要靠临床特点、血生化检测、影像学检查,应提高对该病的认识和重视,早发现、早治疗。[Abstract] Metabolic bone disease of prematurity(MBDP) is due to lack of premature infants with congenital body of calcium,phosphorus and other minerals reserve,after birth due to the parenteral nutrition and other factors ,calcium and phosphorus absorption lead to abnormal bone metabolism,bone mineral content and bone mineral density are decreased.The disease not only affect the growth of children but also the adult , which significantly affect the height of school age in children,and may be one of the causes lead to osteoporosis in their late life.The diagnosis depends mainly on clinical features,biochemical tests,imaging tests.We should pay attention to this disease and prevent it by early detection and early treatment.[Key words] Prematurity; Metabolic bone disease随着医疗新技术的发展及 NICU 救治水平的提高,越来越多的早产儿特别是极低出生体重儿(VLBW)得以存活,代谢性骨病的发病率也日益增高,早产儿代谢性骨病(metabolic bone disease of prematurity,MBDP)是由于骨小梁数量减少、骨皮质变薄等所致的机体骨组织含量减少,伴或者不伴有佝偻病样体现,严重者甚至发生骨折[1],可影响患儿生长乃至成年后骨骼发育。现将早产儿代谢性骨病的研究进展作一综述。1 病因及影响因素1.1 早产儿维生素 D 水平维生素 D(vitamin D,VD)是影响钙生物运用度的一种重要因素。其水平受胎儿出生时机体储藏量多少的影响,而后者与胎龄及母体内维生素 D 水平有关。早产儿母体维生素 D 储藏少或缺少,住院后在日光照射减少等均会造成出生后体内的维生素 D 水平偏低。纯母乳喂养,肾性骨病,增加维生素 D 代谢的药品如苯妥英钠和苯巴比妥...