针刺对肥胖大鼠海马组织一氧化氮含量和一氧化氮合酶活性的影响-进口一氧化氮片

下载后可任意编辑针刺对肥胖大鼠海马组织一氧化氮含量和一氧化氮合酶活性的影响_进口一氧化氮片针刺对肥胖大鼠海马组织一氧化氮含量和一氧化氮合酶活性的影响_进口一氧化氮片 [摘 要]目的：探讨针刺对肥胖大鼠海马组织一氧化氮(NO)含量和一氧化氮合酶(NOS)活性的影响。方法：观察针刺治疗前后肥胖大鼠体重、体脂及海马组织 NO 含量和 NOS 活性的变化。结果：肥胖大鼠体重、体脂及海马组织 NO 含量和 NOS 活性均显着高于正常大鼠水平；大鼠海马组织 NO 含量和 NOS 活性与体重和 Lee’s 指数高度正相关。针刺治疗取得良好减肥疗效。同时，肥胖大鼠海马组织 NO 含量和 NOS 活性明显回降。结论：海马组织 NO 含量和 NOS 活性异常可能是肥胖发病 因素之一；针刺对肥胖机体海马组织 NO 含量和 NOS 活性的良性调整作用，可能是实现减肥效 应的中枢作用机制之一。 [主题词]针刺；肥胖；海马/化学；一氧化氮/分析；一氧化氮合酶* Effects of acupuncture on contents of nitric oxide and nitric oxides ynthase in the hippocampus in the obese rat Liu Zhicheng1, Sun Fengmin2, Zhu Miaohua1, et al. (1.Nanjing University ofTraditional Chinese Medicine and Pharmacology, Jiangsu xxxx, China; 2.Nanjing Population Administration College) xxxxT Objective To study effect of acupuncture on the c ontent of nitric oxide (NO) and the activity of nitric oxide synthase (NOS) in the hippocampus of the obese rat. Methods The changes of body we ight, body fat, 1下载后可任意编辑 and content of NO and activity of NOS in the hippocampus befor e and after acupuncture were observed. Results The body weight, body fat, and the content of NO and the activity of NOS in the hippocampus all were significantly higher than those in the normal rat; there were high positive correlation of the levels of NO and activities of NOS in the hippocampus with the body weight, Lee’s index; after acupuncture treatment, the marked weight reduction effect was achieved, and the level of NO and the...