摘要取代芳香酰肼化合物具有抗菌、止痛、降血压、抗结核、抗肿瘤等多方面的生物活性。本文以苯甲酸、苯并三氮唑、二氯亚砜及水合肼等为原料,经两步反应合成了目标产物取代芳香酰肼。对合成目标产物的结构经IR,MS进行了确证。关键词:苯甲酸;苯并三氮唑;水合肼;合成ABSTRACThydrazidecompoundsexhibitwidespreadbiologicalactivitiessuchasanalgesic,hypotensive,antibacterial,antituberculous,anti-tumorandsoon.Inthisthesis,replacethearomatichydrazidecompoundsweresynthesizedusingaromaticacid,1H-Benzotriazole,2chlorosulfoxideandhydrazinehydrateasrawmaterialsbytwo-stepsreaction.ThestructureoftitlecompoundwasconfirmedbyIR,MS.Keywords:replacethearomatichydrazide;aromaticacid;1H-Benzotriazole;2chlorosulfoxide;synthesis目录摘要................................................................................................................................................iABSTRACT....................................................................................................................................ii第一章前言..............................................................................................................................-1-1.1芳香酰肼类衍生物生物活性的研究............................................................................-1-1.1.1芳香酰肼类衍生物抗菌活性的研究.................................................................-1-1.1.2芳香酰肼类衍生物抗肿瘤活性的研究.............................................................-3-1.1.3芳香酰肼类衍生物合成绿色新农药的研究......................................................-4-1.2芳香酰肼合成方法的研究进展....................................................................................-5-1.2.1酯与水合肼反应合成酰肼.................................................................................-5-1.2.2苯甲酰氯与肼溶液反应合成酰肼.....................................................................-5-1.2.3氨基保护法.........................................................................................................-6-1.3本课题的提出................................................................................................................-7-第二章实验部分......................................................................................................................-8-2.1仪器与试剂...................................................................................................................-8-2.2实验方法.......................................................................................................................-9-2.2.1实验准备........................................................................................................-9-2.2.2化合物苯甲酰基苯幷三氮唑的制备..............................................................-9-2.2.3取代芳香酰肼的制备....................................................................................-10-2.2.4产物的表征.....................................................................................................-10-第三章结果与讨论.................................................................................................................-11-3.1取代芳香酰肼的合成方法的改进..............................................................................-11-3.2目标产物酰肼合成条件的优化..............................................................................