药学 柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究

目录柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究目 录 中文摘要……………………………………………………1 英文摘要……………………………………………………2 研究论文……………………………………………………3 引 言……………………………………………………3 材料与方法……………………………………………........4 结 果………………………………………………........7 讨 论……………………………………………………8 结 论…………………………………………………....9 参考文献................................................................................10 附 图………………………………………………........11 综 述… ………………………...………………………12 致 谢……………………………………………………17 个人简历……………………………………………………181柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究摘 要 目的：观察柴胡疏肝散（CSGS）对四氯化碳（CCl4）引起的小鼠急性肝损伤的保护作用。方法：将小鼠分为正常组，模型组，给药组，采用四氯化碳建立损伤模型，给药组采用柴胡疏肝散（CSGS）进行给药干预，计算肝脏指数并观察肝组织 HE 染色结果。结果：与正常组比较，四氯化碳组的肝组织 HE 染色切片的病理变化说明模型制作成功。与四氯化碳组比较，给药组的肝组织染色切片表明给药组小鼠肝损伤情况减轻。结论：柴胡疏肝散对四氯化碳所致的急性肝损伤有显著的保护作用。 关键词: 四氯化碳；急性肝损伤；柴胡疏肝散2英文摘要STUDY ON THE PROTEEFFECT OF CHAIHU SHU GAN SAN ON ACUTE LIVER INJURY INDUCED BY CARBON TETRACHLORIDEyAbstract Objective: Study of Chaihu Shu Gan San(CSGS) on acute liver injury induced by carbon tetrachloride（CCl4）. Methods:The mice were divided into four groups:normol,model,and drug groups. By giving carbon tetrachloride causes acute liver injury model in mice,the drug group was pretrated by CSGS. After the mice were sacrificed,the hepatic indices were caclulated, histopathological changes of liver tissue slices stained by HE staining were observed under light microscope. Results:Compared t...