精品文档---下载后可任意编辑Maspin 与 uPA 在大肠癌中的表达及临床意义的开题报告(Title) Expression and Clinical Significance of Maspin and uPA in Colorectal Cancer(Abstract) Colorectal cancer is a common malignant tumor of the digestive system, with high incidence and mortality rates. Maspin and uPA are two proteins that play important roles in tumor development and metastasis. The purpose of this study is to investigate the expression and clinical significance of Maspin and uPA in colorectal cancer.(Methods) In this study, 120 patients with colorectal cancer who underwent surgical resection were enrolled. The protein expression levels of Maspin and uPA were detected by immunohistochemistry. The correlation between Maspin and uPA expression levels and clinical variables such as TNM stage, lymph node metastasis, and distant metastasis was analyzed.(Results) The positive expression rates of Maspin and uPA in colorectal cancer specimens were 67.5% and 56.7%, respectively. Maspin expression was negatively correlated with TNM stage, lymph node metastasis, and distant metastasis. In contrast, uPA expression was positively correlated with these clinical variables. Patients with high Maspin expression had longer overall survival (OS) and disease-free survival (DFS) times, while those with high uPA expression had shorter OS and DFS times.(Conclusions) Maspin and uPA are both involved in the development and progression of colorectal cancer. Maspin may act as a tumor suppressor by inhibiting tumor invasion and metastasis, while uPA may promote tumor growth and metastasis. The expression levels of Maspin and uPA may serve as potential prognostic biomarkers for colorectal cancer. Targeting these proteins may provide new therapeutic strategies for the treatment of colorectal cancer.
