YB-1-RNAi对肺腺癌细胞A549中MACC1基因表达影响的研究的开题报告

精品文档---下载后可任意编辑YB-1 RNAi 对肺腺癌细胞 A549 中 MACC1 基因表达影响的讨论的开题报告摘要：调控肿瘤细胞转移相关因子的表达是抑制肺腺癌转移的新策略。MDA-9/GRIM19 调节源于 Adenovirus E1A 和 Ras 激活双重信号通路，是肺腺癌转移相关因子。MACC1 是一种新型肿瘤转移致瘤因子，与肺癌细胞转移有关。本讨论旨在通过 YB-1 RNAi 干扰技术，讨论其对肺腺癌细胞 A549 中 MACC1 基因表达的影响，为肺腺癌转移的治疗提供新的靶点。关键词：YB-1；RNAi；肺腺癌；MACC1；转移Abstract:Regulating the expression of tumor cell metastasis-related factors is a new strategy to inhibit lung adenocarcinoma metastasis. MDA-9/GRIM19 regulates the double signal pathway activated by Adenovirus E1A and Ras, which is a lung adenocarcinoma metastasis-related factor. MACC1 is a new type of tumor metastasis and oncogenic factor associated with lung cancer cell metastasis. The aim of this study is to investigate the effect of YB-1 RNAi interference technology on the expression of MACC1 gene in lung adenocarcinoma cells A549, and to provide new targets for the treatment of lung adenocarcinoma metastasis.Keywords: YB-1; RNAi; lung adenocarcinoma; MACC1; metastasis