精品文档---下载后可任意编辑αβ 类蛋白质折叠类型分类方法讨论中期报告摘要：αβ 类蛋白质是一类具有重要生物学功能的蛋白质，其结构折叠类型的分类方法一直是结构生物学领域的讨论热点之一。本文综述了目前常用的 αβ 类蛋白质折叠类型分类方法，并分析了它们的优缺点，讨论了分类方法的重要性以及未来可能的讨论方向。在目前的分类方法中，SCOP和 CATH 是最为广泛应用的两个分类系统。SCOP 系统以结构和进化为基础，注重分类结果的可读性，但是分类过程较为复杂；CATH 系统以结构和功能为基础，注重分类结果的可靠性和准确性，但是分类粒度较细且分类结果需要人工修正。此外，一些新的分类方法如FRankenstein、PDB-care 和 HOMSTRAD 等也在不断讨论和探究中。继续完善 αβ 类蛋白质折叠类型分类方法有助于更深化地理解蛋白质的结构与功能以及生物学进化。关键词：αβ 类蛋白质；折叠类型；分类方法；SCOP；CATH；FRankenstein；PDB-care；HOMSTRADAbstract:Alpha-beta proteins are a class of proteins with important biological functions, and the classification method of their structure folding types has always been a hot topic in the field of structural biology. This article reviews the currently commonly used classification methods for alpha-beta proteins folding types, analyzes their advantages and disadvantages, discusses the importance of classification methods, and possible research directions in the future. Among the currently used classification methods, SCOP and CATH are the two most widely used classification systems. The SCOP system is based on structure and evolution, focusing on readability of classification results, but the classification process is more complex; the CATH system is based on structure and function, focusing on the reliability and accuracy of classification results, but the classification granularity is relatively fine and the classification results need to be manually corrected. In addition, some new classification methods such as FRankenstein, PDB-care, and HOMSTRAD are also being continuously researched and explored. Continuously improving the classification method of alpha-beta protein folding types helps to deepen our understanding of the structure and function of proteins and biological evolution.精品文档---下载后可任意编辑Keywords: alpha-beta proteins; folding types; classification method; SCOP; CATH; FRankenstein; PDB-care; HOMSTRAD
