精品文档---下载后可任意编辑两株抗结核分枝杆菌(TB)活性植物内生链霉菌代谢产物讨论的开题报告摘要：结核病是一种严重的传染病，抗结核分枝杆菌是常见的结核病治疗药物。本论文旨在讨论两株具有抗结核活性的植物内生链霉菌产生的代谢产物，并探究其可能的药理作用机制。首先，将使用分离纯化技术从两株植物种子中分离出链霉菌，然后通过生物学、化学和分析技术鉴定其种属及代谢产物。接下来，将通过抗结核药物敏感性测试和结构活性关系分析评估链霉菌产生的代谢产物对结核杆菌的抑制作用。最后，将运用分子生物学技术进一步探究链霉菌代谢产物的作用机制。关键词：结核病；抗结核分枝杆菌；链霉菌；代谢产物；药理作用机制。Abstract:Tuberculosis is a serious infectious disease, and anti-tubercular drugs are commonly used in tuberculosis treatment. This thesis aims to investigate the metabolites produced by two strains of plant endophytic Streptomyces with anti-tuberculosis activity, and explore their possible pharmacological mechanisms. Firstly, isolation and purification techniques will be used to isolate Streptomyces from the seeds of two plants, and then its genus and metabolites will be identified by biological, chemical and analysis techniques. Subsequently, the inhibitory effect of the metabolites produced by Streptomyces against Mycobacterium tuberculosis will be evaluated by anti-tubercular drug sensitivity testing and structure-activity relationship analysis. Finally, molecular biology techniques will be used to further explore the pharmacological mechanisms of Streptomyces metabolites.Keywords: tuberculosis; anti-tubercular drugs; Streptomyces; metabolites; pharmacological mechanisms.
