精品文档---下载后可任意编辑雪地茶中所含有效成分松萝酸口服高生物利用度制剂的讨论的开题报告【中文摘要】 雪地茶是一种天然植物性食品，具有一定的保健效果，被广泛应用于医药和保健领域。其中松萝酸是一种重要的活性成分，具有镇痛、抗炎、抗感染等生物活性，但其口服制剂的生物利用度较低，限制了其临床应用。考虑采纳新的机制来提高松萝酸的生物利用度：通过制备纳米粒子、脂质体、微乳等高效载体促进松萝酸吸收，并通过改变制剂 pH 值、添加辅助剂等措施提高其口服吸收和生物利用度，以实现松萝酸的改善药效和减少不良反应。【英文摘要】 Snow tea is a natural plant-based food with certain health benefits, widely used in the medical and health fields. Pinus roxburghii Sarg (Pinaceae) contains important biologically active ingredients, such as pinus roxburghii sarg (PRS), which has a variety of biological activities such as analgesic, anti-inflammatory, and anti-infection. However, the low bioavailability of PRS in oral formulations limits its clinical application. In this context, new mechanisms are needed to improve the bioavailability of PRS: by preparing high-efficiency carriers such as nanoparticles, liposomes, and microemulsions to promote the absorption of PRS, and by changing the pH of the formulation and adding auxiliary agents to improve its oral absorption and bioavailability, thus achieving the improvement of the effect of PRS and reducing adverse reactions.
