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Chemical Engineering and Processing： Process IntensificationVolume 47， Issue 12， November 2024, Pages 2256–2261Extraction of isoflavonoids from Pueraria by combining ultrasound with microwave vacuumYang Hua, Tao Wanga, MingxiaoWangb， Sufang Hana, Pingyu Wana， Maohong Fanc， a Beijing University of Chemical Technology, Beijing 100029, China b General Hospital of China National Coal Group Corp., Beijing 110013, China c School of Materials Science and Engineering, Georgia Institute of Technology， Atlanta， GA 30332—0245， USAReceived 24 December 2024. Revised 30 September 2024。 Accepted 12 December 2024。 Available online 11 January 2024.http://dx。doi.org/10。1016/j。cep.2024.12。013, How to Cite or Link Using DOIPermissions & ReprintsAbstractThis study proposes a new method to quickly extract and dry isoflavonoids from Pueraria Lobata Ohwi (Pueraria) by combining ultrasound and microwave technologies. The time required to extract isoflavonoids at comparable levels of production by ultrasound disruption was 20 times shorter than by conventional reflux extraction. Moreover, test results for drying the extracted substance from Pueraria show that the microwave—vacuum method is 10 times faster than the conventional two-step vacuum approach。 Finally, different instrumental analyses of isoflavonoids obtained from Pueraria using the proposed new method show that extraction by ultrasound disruption and microwave—vacuum drying affects neither the structure nor the composition of the extracted substance.Keywords：Extraction； Isoflavonoids； Microwave drying； Ultrasound1. IntroductionUltrasound has been used to extract compounds from the various parts of plants for more than three decades [1 ］ 。 Due to the disrupti...