·综 述·PPAR-β 在脓毒症肝损伤中的保护作用李娜娜1，张馨予1，杨威1，孟祥林1，赵鸣雁1，于凯江1，刘微2，康凯11. 哈尔滨医科大学附属第一医院重症医学科（哈尔滨 150000）2. 哈尔滨医科大学附属第一医院病理科（哈尔滨 150000）【摘要】 目的 总结过氧化物酶体增殖物激活受体-β（PPAR-β）对脓毒症肝损伤的保护作用及其机制，为脓毒症肝损伤的防治提供新的思路。方法 收集 PPAR-β 在脓毒症肝损伤中的作用的相关文献并进行综述。结果 PPAR-β 在细胞存活、抗炎及抗氧化方面发挥着重要作用，它作用于多种病理生理过程，能减少炎症因子的活化，减少氧自由基的产生，抑制凋亡蛋白的表达，从而发挥抗炎、抗氧化及抗凋亡的作用。结论 PPAR-β 可以抑制核因子-κB 的活化和减少炎症因子释放，减轻细胞凋亡，通过抗氧化减轻肝损伤，从而降低脓毒症肝损伤的致死率。【关键词】 脓毒症肝损伤；过氧化物酶体增殖剂激活受体-β；综述Protective effect of PPAR-β on liver injury in sepsisLI Nana1, ZHANG Xinyu1, YANG Wei1, MENG Xianglin1, ZHAO Mingyan1, YU Kaijiang1, LIU Wei2, KANGKai11. Department of Intensive Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, P. R. China2. Department of Pathology, The First Affiliated Hospital of Harbin Medical University, Harbin 150000, P. R. ChinaCorresponding author: KANG Kai, Email: janekk79@126.com【Abstract】 Objective To summarize the protective effect of peroxisome proliferator-activated receptor-beta(PPAR- β) in sepsis-induced liver injury and the mechanism, and to provide new ideas for the prevention and treatment ofsepsis-induced liver injury. Methods Relevant literatures about protective effect of PPAR-β in sepsis-induced liver injurywere collected and reviewed. Results PPAR- β played an important role in cell survival, anti-inflammatory, and anti-oxidation. It acted on a variety of pathophysiological processes, could reduce the activation of inflammatory factors,reduced the production of oxygen free r...
