抗胸腺细胞免疫球蛋白所致心脏毒性及其影响因素【摘要】 目的 探讨抗胸腺细胞免疫球蛋白对心脏的毒副作用及相关影响因素。方法 回顾性分析 108 位患者使用抗胸腺细胞免疫球蛋白前后心电图、胸片、心肌酶的变化及所致心脏毒性临床表现。分析抗胸腺细胞免疫球蛋白致心脏毒性的危险因素，先对各变量进行单因素分析，然后将单因素分析有意义的变量纳入 logistic 回归进行多因素分析。结果 50 例患者出现心脏毒性，发生率%。单因素分析结果显示：出现心脏毒性组中年龄、肿瘤患者人数、马利兰和环磷酰胺使用人数均大于或多于未出现心脏毒性组 ()。 logistic 多因素分析结果显示：年龄和 Bu 的使用是增加心脏毒性发生的危险因素。结论 ATG 致心脏毒性的发生较为普遍；年龄和 Bu 的使用是增加心脏毒性发生的危险因素。【关键词】 抗胸腺细胞免疫球蛋白；心脏毒性；影响因素 Abstract:Objective To investigate the influence of antithymocyte immunoglobulin on heart function and its affecting factors. Methods A retrospective study of 108 patients on ECG, X-ray films, alterations of myocardial enzymes were carried out, all of patients were administered with antithymocyte immunoglobulin. These patients were divided into two groups based on whether cardiotoxity occurred. GroupA：cardiotoxity occurred. GroupB: cardiotoxity did not occur. Univariate and multivariate analyses (logistic regression) were conducted to identify the affecting factors. Results The incidence of cardiac toxicity was %. The result of univariate analysis showed that the age of the patients with the symptoms of cadiotoxicity in the group A was older than that in the group B, and the number of patients with tumor, the number of patients administered with busulfan (Bu) and cyclophosphamide (Cy) in the group A were more than those in the group B(). Logistic regression identified that age and Bu were risk factors for It is indicated that patients administered with antithymocyte immunoglobulin had hig...
