抗苗勒管激素对卵泡发育的影响VIP专享

抗苗勒管激素对卵泡发育的影响【摘要】 目的 探讨血清抗苗勒管激素(AMH)水平对促排卵效果的影响。方法 排卵障碍患者 70 例，其中多囊卵巢综合征 40 例，非 PCOS 者 30 例，尿促性素促排卵。月经周期 2～3 d 及注射绒促性素日抽取空腹静脉血测 AMH、雌激素(E)及雄激素(T)水平，分析血清 AMH 水平与促排卵效果的关系。20 例健康妇女做正常对比。结果 PCOS 组血清基础 AMH 为(±)pmol/L，明显高于非 PCOS 组及对比组(P＜)，后两组间的基础 AMH 差异无统计学意义。非 PCOS组基础 AMH 水平低者，促排卵药用量大，获得的成熟卵泡少；而 PCOS 组基础 AMH 水平低者促排卵药用量小，获得的成熟卵泡多。结论 血清基础 AMH 水平对不同排卵障碍患者的影响是不同的，PCOS 患者血清基础 AMH 水平低，促排卵效果好，而非 PCOS患者血清基础 AMH 水平低，预示促排卵效果差。【关键词】 抗苗勒管激素；排卵障碍；多囊卵巢综合征；促排卵 Abstract： Objective To observe the influence of serum anti müllerian hormone (AMH) basal levels on ovulation Seventy patients of anovulatory patients were treated with human menopausal gonadotropin (hMG) for ovulation induction. Among them, 40 suffered from polycystic ovary syndrome (PCOS) (PCOS group), and the other 30 suffered from non PCOS (non PCOS group). Fasting serum levels of AMH, estradiol (E), and testosterone (T) were measured on the second (or third) day of menstrual cycles (basal day) and hCG injection day, respectively. The influence of serum AMH basal levels on ovulation induction were evaluated. Twenty age matched healthy women were chosen as The serum basal AMH level in the PCOS group was ± pmol/L, significantly higher than that in the non PCOS group and that in the controls (), and the difference between the later two groups was not significant. In the non PCOS group, the lower the basal AMH level was, the more the hMG was needed, and the fewer the mature follicles were obtained....