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抗菌药物治疗细菌性肺炎疗效指标与标准的分析

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抗菌药物治疗细菌性肺炎疗效指标与标准的分析【摘要】 目的 分析抗菌药物治疗细菌性肺炎的疗效评价指标和标准,为该病疗效评价标准的建立提供依据。方法 计算机检索 CNKI(1994~)和 CBM(1995~)所收录的相关文献,建立相应的数据库,采纳统计软件包进行统计描述。结果 收集合格文献 481 篇。抗菌药物治疗细菌性肺炎疗效评价指标中综合指标出现的频率最高(%),其次是不良反应发生率(%)和细菌清除率(%),其它指标出现的频率较低。综合指标的疗效评价标准主要依据《抗菌药物临床讨论指导原则》,其构成比为%。结论 目前国内对于细菌性肺炎疗效指标的讨论多采纳综合指标、细菌清除率和不良反应发生率,而单独以临床症状和体征作为疗效评价指标的较少,以病情稳定性、再住院率和基于患者结果的报告作为疗效评价指标在检索的文献中尚未见报道。【关键词】 抗菌药物; 细菌性肺炎; 疗效指标; 疗效标准 ABSTRACT Objective To study the therapeutic effect index and criterion in the treatment of bacterial pneumonia with anti infective drug. Method Literatures concerning bacterial pneumonia were identified from CNKI (1994~) and CBM (1995~). SPSS for windows was adopted for statistical description. Results Four hundred eighty one literatures were included. Frequency of comprehensive index was the topmost at all indexes of therapeutic effect evaluation (%), followed by frequency of adverse reaction rate and bacterial clearance rate, which were % and %, respectively. Evaluation critetion of the comprehensive index mainstaied instruction principle on antibacterials clinical research, the constituent ratio was %. Conclusion Among indexes of therapeutic effect evaluation at present in China, comprehensive index, adverse reaction rate and bacterial clearance rate were used more often, but clinical symptoms and signs were less reported, and report based on the final outcomes, therapeutic stability and readmission rate relating to efficacy evaluation indices was not recorded in the...

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抗菌药物治疗细菌性肺炎疗效指标与标准的分析

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