0233-从药理作用机制角度看中西药干预防治化疗性静脉炎

0233 从药理作用机制角度看中西药干预防治化疗性静脉炎 牟金金 1,周佳,张莹 1,王卓*（第二军医大学长海医院药学部, 上海 202533）摘要：化疗性静脉炎发病机制复杂，近年来临床实践中总结摸索出许多行之有效的干预措施。本文以病因机制和药理作用机制为主线,综述目前临床上用于防治化疗性静脉炎的中西药。关键词：化疗性静脉炎；发病机制；中西药；药理作用Prevention and treatment of chemotherapy-induced phlebitis by Chinese and Western medicine in the perspective of pharmacological mechanism MOU Jinjin, ZHOU Jia, ZHANG Ying, WANG Zhuo (Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 202533)Abstract: Pathogenesis of chemotherapy-induced phlebitis is complicated ,however, in recent years, medical workers summed up a lot of effective intervention measures. In this paper, Chinese and Western medicine for the prevention and treatment of phlebitis are reviewed according to pathogenesis and pharmacological mechanism.Key Words: chemotherapy-induced phlebitis; Pathogenesis; Chinese and Western medicine; pharmacological mechanism化疗性静脉炎是化疗药物临床应用中常见的一种并发症,多因输入浓度较高、刺激性较大的药液或静脉内置管时刻较长而引起局部静脉壁的化学性炎性反应,也可因输液过程中无菌操作不严或血管反复多次穿刺引起局部静脉的感染。如何减轻化疗药物所引起的静脉炎并使之降到最低限度,对保证病人健康的心理状态,顺利完成治疗具有重要意义。近年来临床针对化疗性静脉炎的防治进行了许多的讨论,也取得了不错的成效。然而,关于化疗性静脉炎的具体发生气制及防治药物的确切作用机制则有待进一步深化讨论。本文据现有讨论成果,以病因机制和药理作用机制为主线,对目前临床上用于防治化疗性静脉炎的中西药进行归纳总结。1 中西医防治化疗性静脉炎的不同机制 西医学认为,导致化疗性静脉炎产生的机制有如下几个方面:① 直截了当毒性作用:化疗药物作用于细胞代谢周期的各个时期,在杀伤肿瘤细胞的同时,对正常的细胞和组织亦有一定的损害,能够使血管内皮细胞坏死脱落。②药物引起血浆 pH 值改变:血浆正常 pH 值为 7.35～7.45 ,超过此范畴不...