生物膜与带蒂筋膜瓣体内构建组织工程复合体修复兔骨缺损的比较VIP免费

中国组织工程研究与临床康复第15卷第3期2011–01–15出版JournalofClinicalRehabilitativeTissueEngineeringResearchJanuary15,2011Vol.15,No.3P.O.Box1200,Shenyang110004cn.zglckf.com386DepartmentofOrthopaedics,FirstAffiliatedHospitalofHebeiNorthUniversity,Zhangjiakou075000,HebeiProvince,ChinaMengXian-yong★,Master,Attendingphysician,DepartmentofOrthopaedics,FirstAffiliatedHospitalofHebeiNorthUniversity,Zhangjiakou075000,HebeiProvince,Chinayfymxy@yahoo.cnCorrespondenceto:YangXin-ming,Professor,Master’ssupervisor,DepartmentofOrthopaedics,FirstAffiliatedHospitalofHebeiNorthUniversity,Zhangjiakou075000,HebeiProvince,Chinayxm1120@sohu.comSupportedby:MedicalScientificResearchKeyProgramofHebeiProvinceScientificResearchandDevelopmentPlanbyScienceandTechnologyBureauofHebeiProvincein2009,No.09276102D-46*;MedicalScientificResearchKeyProgrambyHealthBureauofHebeiProvincein2010,No.20100481*;ScientificResearchandDevelopmentGuidePlanofZhangjiakouin2010No.1021083D*;ScientificResearchInstructionProgramofHebeiNorthUniversityin2009,No.2009037*Received:2010-07-14Accepted:2010-08-11生物膜与带蒂筋膜瓣体内构建组织工程复合体修复兔骨缺损的比较****★孟宪勇，杨新明，齐志民，王耀一，白瑞ComparisonofpediclefascialflapandabsorbablebiomembraneinconstructingtissueengineeringbonetorepairrabbitbonedefectsMengXian-yong,YangXin-ming,QiZhi-min,WangYao-yi,BaiRuiAbstractBACKGROUND:Tissueengineeringboneconstructedusingbothpediclefascialflapandabsorbablebiomembranecaneffectivelypromotethebonedefectrepair,butthereisnotenoughstudyaboutthecomparisonbetweenthem.OBJECTIVE:Toobservethebonereparativeeffectoftissueengineeringbonewrappedbypediclefascialflapandbysimplebiomembrane.METHODS:A1-cmbonedefectmodelwasproducedinrabbitbilateralulnamiddlesegmentandperiosteum.Autologousredbonemarrowwasimplantedintheosteoinductiveabsorbingmaterialcontainingbonemorphogeneticproteintoprepareuncellulartissueengineeringbone,whichwasthenimplantedintothebilateralbonedefectareas.Theleftsidewaswrappedbypediclefascialflapastheexperimentgroup,whiletherightsidewaswrappedbysimpleabsorbablebiomembraneasthecontrolgroup.At4,8,12,16weeksaftertheoperation,eachgroupwasexaminedbyX-rayradiograph,grossmorphologyandhistologicalexamination,boneshapemeasurementanalysisinthereparativeareawasperformed,thebiomechanicaldetectionwasdoneat12weekstocomparetherepairofbonddefectintwogroups.RESULTSANDCONCLUSION:TheexperimentgroupwassuperiortothecontrolgroupregardingtheX-rayradiograph,grossmorphologyandhistologicalinspection,thequantityandtheformingspeedofbonetrabeculaandcartilaginoustissues,theformationofmaturebonestructure,theremodelingofdiaphysisstructure,therecanalizationofcavumossis,theabsorptionanddegradationoftheimplant,theratioofnewbonetrabeculaareatototalreparativeareaandthefinalbiomechanicalstrength(P<0.05).Theoutcomesindicatedthatthetechnologyofmembraneguidedboneregenerationusingpedicalfascialflaptorepairlarge-segmentbonedefectcanrestrictthegrowthoffibrousconnectivetissueinthereparativeprocess,andpromotetheeffectiveandfastvascularization,accordinglyacceleratetheprocessandtheeffectoftransformingimplantedbonetoautologousbone.MengXY,YangXM,QiZM,WangYY,BaiR.Comparisonofpediclefascialflapandabsorbablebiomembraneinconstructingtissueengineeringbonetorepairrabbitbonedefects.ZhongguoZuzhiGongchengYanjiuyuLinchuangKangfu.2011;15(3):386-390.[http://www.crter.cnhttp://en.zglc...