现代药物与临床Drugs&Clinic第29卷第12期2014年12月·1410·递法明片改善儿童高度近视弱视的临床观察奉辉，邓宏伟，周薇薇深圳市眼科医院深圳眼科学重点实验室，广东深圳518040摘要：目的观察递法明片改善高度近视弱视患儿的临床疗效和安全性。方法选取2012年10月—2013年10月深圳市眼科医院收治的高度近视弱视患儿200例，随机分为治疗组和对照组，每组各100例。治疗组口服递法明片，1片/次，2次/d。对照组口服淀粉片1片/次，2次/d。两组均连续用药6个月。观察两组治疗后3、6个月、随访6个月视力、屈光度、眼轴、角膜屈光力、角膜厚度等的变化。结果治疗6个月、随访6个月后，治疗组患儿平均视力得到提高，与治疗前比较差异有统计学意义（P＜0.05），对照组治疗前后视力差异无统计学意义；治疗6个月、随访6个月后，治疗组视力优于对照组，两组比较差异有统计学意义（P＜0.05）。治疗6个月、随访6个月后，治疗组屈光度、眼轴、角膜厚度均较治疗前有很多改善，治疗前后差异有统计学意义（P＜0.05）；且治疗组这些指标优于对照组，两组比较差异有统计学意义（P＜0.05）。随访6个月后，对照组屈光度、眼轴、角膜厚度较治疗前有所增长，治疗前后差异有统计学意义（P＜0.05）。结论递法明片能明显改善高度近视弱视患儿的视力，降低屈光度、眼轴及角膜厚度，对高度近视弱视患儿有一定的疗效。关键词：递法明片；淀粉片；高度近视；弱视；屈光度；眼轴；角膜厚度中图分类号：R985文献标志码：A文章编号：1674-5515(2014)12-1410-04DOI:10.7501/j.issn.1674-5515.2014.12.020ClinicalobservationofDifamingTabletsinimprovementofhighmyopiaandamblyopiaofchildrenFENGHui,DENGHong-wei,ZHOUWei-weiShenzhenKeyLaboratoryofOphthalmology,OphthalmologyHospitalofShenzhenCity,Shenzhen518040,ChinaAbstract:ObjectiveToexploretheefficacyofDifamingTabletsinimprovementofhighmyopiaandamblyopiaofchildren.MethodsPatients(200cases)withhighmyopiaandamblyopiaofchildrenfromOctober2012toOctober2013intheOphthalmologyHospitalofShenzhenCitywererandomlydividedintotreatment(100cases)andcontrol(100cases)groups.ThepatientsinthetreatmentgroupwerepoadministeredwithDifamingTablets,onetablet/time,twicedaily.ThepatientsinthecontrolgroupwerepoadministeredwithStarchTablets,onetablet/time,twicedaily.Thepatientsinthetwogroupsweretreatedforsixmonths.Thechangesofeyesight,diopter,eyeaxis,cornealrefractivepower,andcornealthicknessinthetwogroupsafterthetreatmentof3,6months,andfollowedupfor6monthswereobserved.ResultsTheaverageeyesightinthetreatmentgroupwasimprovedafterthetreatmentof6months,andfollowedupfor6months,andthedifferenceswerestatisticallysignificantbeforeandafterthetreatmentinthesamegroup(P<0.05).Theeyesightinthecontrolgroupwasnostatisticallysignificantdifferencebeforeandafterthetreatment.Theeyesightinthetreatmentgroupwasbetterthanthatincontrolgroupafterthetreatmentof6months,andfollowedupfor6months,withthesignificantdifferencebetweenthetwogroups(P<0.05).Thediopter,eyeaxis,andcornealthicknessinthetreatmentgroupwereimprovedafterthetreatmentof6months,andfollowedupfor6months,andthedifferenceswerestatisticallysignificantbeforeandafterthetreatmentinthesamegroup(P<0.05).Theseindicatorsinthetreatmentgroupwerebetterthanthoseinthecontrolgroup,withthesignificantdifferencebetweenthetwogroups(P<0.05).Thediopter,eyeaxis,andcornealthicknessinthecontrolgroupwereincreasedfollowedupfor6months,andthedifferenceswerestatisticallysignificantbeforeandafterthetreatmentinthesamegroup(P<0.05).ConclusionsDifamingTabletscanobviouslyimprovetheeyesightofhighmyopiaandamblyopiaofchildren,andcanreducethediopter,eyeaxis,andcornealthickness,whichhasthecertaincurativeeffectfo...
