呼吸频率对兔心率变异和血压的影响*闫世彪1摇刘仁光1摇沈仲元2[摘要]摇目的摇观察呼吸频率对兔心率变异(HRV)和血压的影响。方法摇建立兔控制呼吸模型,用呼吸机控制呼吸频率(40,50,60次/分)和潮气量(10ml/kg),用生理记录仪记录呼吸、心电、血压波形。观察呼吸运动对RR间期(RRI)及血压的影响;呼吸频率对RRI及血压波动幅度的影响;呼吸频率对HRV、血压变异(BPV)、呼吸峰中心频率的影响;呼吸频率对HRV影响采用传统HRV和eHRV(enhancedHRV)方法分析并对两结果加以比较。结果摇淤RRI、血压波动周期与呼吸周期呈同步变化;于与呼吸频率50次/分相比,40次/分使RRI及血压的波动幅度增大,60次/分使RRI及血压波动幅度减小;盂HRV和BPV的呼吸峰中心频率相同,50次/分时高频峰在低频与高频交界处,与呼吸频率50次/分相比,40次/分使呼吸峰中心频率左移至低频段,60次/分使呼吸峰中心频率右移,完全在高频段;榆传统HRV分析结果示:随呼吸频率增加LF、LFnorm逐渐减小,HF、HFnorm逐渐增大;eHRV分析结果示:与呼吸频率50次/分相比,40次/分使HFnorm(高频标化值)减小,LFnorm(低频标化值)和LF/HF增大;60次/分使HFnorm增大,但差异均无显著性。结论摇RRI及血压的波动周期与呼吸周期相同,减慢呼吸频率使RRI及血压波动幅度增加,HRV、BPV呼吸峰中心频率左移,加快呼吸频率使RRI及血压波动幅度减小,HRV、BPV呼吸峰中心频率右移,但一定程度内的呼吸频率波动对eHRV分析结果无显著影响。[关键词]摇心血管病学;心率变异;血压;血压变异;呼吸频率;自主神经系统DOI:10.7695/zgxzqb201303015网络出版时间:网络出版地址:中图分类号摇R540.4+1摇摇文献标识码摇A摇摇文章编号摇1007-2659(2013)03-0239-05*摇国家自然科学基金资助项目(项目编号:81072853)作者单位:1摇辽宁医学院附属第一医院(辽宁锦州121001)2摇上海中医药大学(上海200030)作者简介:闫世彪(1983-),男(汉族),山东菏泽人,住院医师,医学硕士,主要从事心律失常诊治。通讯作者:刘仁光,E鄄mail:liurenguanglaoshi@126.comTheeffectofrespiratoryfrequencyonrabbitheartratevariabilityandbloodpressure.YANShi鄄biao1,LIURen鄄guang1,SHENZhong鄄yuan2.1TheFirstAffiliatedHospitalofLiaoningMedicalCollege,Jinzhou121001,Liaoning,Chi鄄na;2ShanghaiUniversityofTraditionalMedicine,Shanghai200030,ChinaCorrespondingauthor:LIURen鄄guang,E鄄mail:liurenguanglaoshi@126.com[Abstract]摇Objective摇Toobservetheimpactofrespiratoryfrequency(RF)onheartratevariability(HRV)andbloodpres鄄sure(BP).摇Methods摇Establishtherabbitmodelofcontrolledrespiration,theventilationrateandtidalvolumewerepresetbybreathingmachine,SKY鄄A4anelectrophysiolographwasusedtorecordrespiratory,ECGandBPwaveform.Toobservetheim鄄pactofinspirationandexpirationonRRinterval(RRI)andBP,ofventilationrateonRRI,BP,andthecentralfrequencyofre鄄spiratorypeak,HRVfrequencyspectra.TwomethodstraditionalandenhancedHRVwereadoptedtoanalyzeHRV.摇Results摇淤RRIandBPcyclicalchangecoincidedwiththerespiratorycycle.于ventilationratecouldaffecttheamplitudeofRRIandBPcyclicalchange.Comparedwith50bpm,40bpmcouldincreasetheamplitudeand60bpmcoulddecreasetheamplitudeofcycli鄄calchange.盂thecentralfrequencyofrespiratorypeakwouldshifttorightasventilationrateincrease.RF40bpm,itwastotal鄄lylocatedwithintherangeofLF.50bpm,itwaslocatednearthejunctionofHFandLF.60bmp,itwastotallylocatedwithintherangeofHF.榆traditionalHRVanalysisresults:LF,LFnormdecreased,andHF,HFnormwereventilationratewouldnotchange.HRVfrequencyspectrasignificantlyincreasedasrespiratoryfrequencyincreasing.TherewasnostatisticalsignificancefoundintheHRVfrequencyspectrabetweendifferentventilationrate.摇Conclusion摇RRIandBPcyclicalchangecoincideswiththerespiratorycycle,theamplitudeofRRIandBPcyclicalchangewouldincreaseandtheHRVrespiratorypeakwouldshiftt...
