·128·doi:10.主耍结畲13年6月第5卷第3期ResearchofIntegratedTraditionalChinesndWestMMedifie2013JMPVo1.5No.33969/j.issn.1674-4616.2013.03.006颈复康颗粒治疗神经根型颈椎病的系统评价张鸿升周宾宾谢忠文李翔刘广宇。△广西中医药大学,南宁530001广西中医药大学附属第一医院,南宁530001。黑龙江中医药大学附属第二医院,哈尔滨150001摘要目的运用系统评价颈复康颗粒治疗神经根型颈椎病的有效性及安全性,了解颈复康颗粒治疗神经根型颈椎病的I临床疗效以及可应用性。方法采用Cochrane系统评价方法,电子检索MED—LINE、EMBASE、Cochrane图书馆临床对照试验资料库、中国生物医学文献数据库、中国期刊全文数据库、重庆维普数据库、万方数据库,由两名评价员独立评价文献质量、提取资料并交叉核对,而后采用RevMan5.2软件进行Meta分析。结果3项研究,共696例患者纳入本次研究。3项研究均以有效率作为主要结局指标。对同质性较强的研究进行Meta分析,显示证据证明颈复康颗粒组对照其他保守疗法组总有效率的Meta分析(OR一5.85,95CI=3.27、10.46,Z=5.96,P(O.O1),颈复康颗粒组对照牵引组总有效率的Meta分析(OR一20.2O,95CI一4.65、87.72,P<0.01),颈复康颗粒组对照美洛昔康分散片组总有效率的Meta分析(OR一2.44,95CI一0.64、9.31,P一0.19),颈复康颗粒对照根痛平颗粒组总有效率的Meta分析(OR=3.62,95CI一1.73、7.59,P一0.0006)。结论目前纳入研究初步显示颈复康颗粒治疗神经根型颈椎病安全,在改善症状、提高整体功能等方面均优于对照组。但由于纳入研究存在选择性偏倚和测量性偏倚的高度可能性,势必影响结果的论证强度,因此临床研究质量有待提高。关键词颈复康颗粒;神经根型颈椎病;安全性;随机对照;系统评价SystematicReviewofJingfukangKelifortheTreatmentofNerveRootCervicalSpondylosisZHANGHongsheng,ZHOUBinbin,XIEZhongwen,etalGuangxiUniversityofTraditionalChineseMedicine,Nanning530001,China。TheFirstAffiliatedHospitalofGuangxiUniversityofTraditionalChineseMedicine,Nanning530001,China。TheSecondAffiliatedHospitalofHeilongjiangUniversityofTraditionalChineseMedicine,Haerbin150001,ChinaAbstractObjectiveToevaluatetheefficacyandsafetyofJingfukangKeliinthetreatmentofNerveRootCervicalSpondylosisandunderstanditsapplicability.MethodsMEDLINE,EMBASE,TheCochraneIibrary,PubMed,VIP,CNKIandCBMwereretrievedtoidentifyrandomizedcontrolledtrialsofJingfukangKeliversusthecontrolinthetreatmentofNerveRootCervica1Spondylosis.Qualityassessmentanddataextractionwereconduc—tedbytworeviewersindependently.Disagreementwasresolvedthroughdiscussion.A1ldatawereanalyzedusingRevMan5.2software.ResultsThreestudies,totalof696caseswereenrolled.Effectiveratewasusedasprimaryoutcomemeasureinallthreestudies.Meta-analysisshowthatJingfukangKeliwassuperbtotheothertherapies(OR一5.85,95Y0CI一3.27,10.46,Z一5.96,P%0.01).TocomparesJingfukangKeliwithwesternmedicine,thereisnosignificantadvantage(OR=2.44,95CI一0.64,9.31,P一0.19).NosignificantadverseeffectsorAllergicreactionswerereported.ConclusionJingfukangKeliiseffectiveinthetreatmentofnerverootcervicalspondylosis.However.duetoahighriskofselectionbiasanddetectionbiasintheincludedstudies,theevidenceiS△通信作者,c0rrespondingauthor,E—mail:1iu580506@163.com中西医结合研究2013年6月第5卷第3期ResearchofIntegratedTraditional—ChineseandWesternMedic—ine2013JuneVo1.5No.3insufficienttodeterminetheeffectofJingfukangKeli.Furtherlarge—scaletrialsarerequiredtodefinetheroleofJingfukangKeliinthetreatmentofnerverootcervicalspondylosis.KeywordsJingfukangKeli;nerverootcervicalspondylosis;safety;randomizedcontrolled;sys...