水、电解质代谢紊乱水、电解质代谢紊乱WaterandElectrolyteImbalanceWaterandElectrolyteImbalance实验室检查:实验室检查:血血pH7.29pH7.29、血清、血清NaNa++123mmol/L123mmol/L、血清、血清Cl¯98mmol/LCl¯98mmol/L、、血清血清KK++3.5mmol/L3.5mmol/L、血浆渗透压、血浆渗透压265mmol/L265mmol/L;;SB16mmol/LSB16mmol/L;血清尿素氮;血清尿素氮9.0mmol/L9.0mmol/L、尿检正常。、尿检正常。CasestudyCasestudy患者:患者:4242岁,男性。岁,男性。22天前因食入不洁食物后出现腹痛,每天天前因食入不洁食物后出现腹痛,每天十多次水样便。昨在本地医院抗炎治疗和输入十多次水样便。昨在本地医院抗炎治疗和输入10001000mlml5%5%葡萄糖,未见好转。葡萄糖,未见好转。查体:查体:口层发紫,皮肤弹性降低,眼窝下陷,脉搏无力,血压口层发紫,皮肤弹性降低,眼窝下陷,脉搏无力,血压85/60mmHg85/60mmHg,尿量,尿量400ml/400ml/日。日。问:问:((11)患者为什么会出现上述症状与体症?)患者为什么会出现上述症状与体症?((22)其发生机制是什么?)其发生机制是什么?生理学基础体液容量与分布体液容量与分布Volume&distributionVolume&distribution水与电解质代谢平衡调节水与电解质代谢平衡调节BalanceofwaterandelectrolytemetabolismBalanceofwaterandelectrolytemetabolism体液的电解质组成体液的电解质组成CompositionofelectrolytesCompositionofelectrolytes((WaterandelectrolytesWaterandelectrolytesbalancebalance))第一节水、电解质代谢第一节水、电解质代谢水、电解质紊乱水、电解质紊乱一、体液容量及其分布一、体液容量及其分布((TotalfluidvolumeanddistributionTotalfluidvolumeanddistribution))Table1ApproximatavolumeofbodyfluidcompartmentsTable1Approximatavolumeofbodyfluidcompartments成人(男)妇女新生儿老年人成人(男)妇女新生儿老年人TBWTBW6050-5580526050-558052*Totalbodywater,TBW;Intracellularfluid,ICF;Extracellularfluid,ECF*Totalbodywater,TBW;Intracellularfluid,ICF;Extracellularfluid,ECF水、电解质紊乱水、电解质紊乱InterstitialfluidInterstitialfluid1514402015144020PlasmaPlasma54555455ICFICF4035352740353527ECFECF2018452520184525((ICFICF))((ECFECF))((InterstitialInterstitialfluidfluid))((PlasmaPlasma))水、电解质紊乱水、电解质紊乱二、体液的电解质组成二、体液的电解质组成((CompositionofelectrolyteinCompositionofelectrolyteinbodyfluidbodyfluidss))TableTable22ELECTROLYTECOMPOSITIONOFBOODFLUIDSELECTROLYTECOMPOSITIONOFBOODFLUIDSCompartmentalconcentration(mEq/L)Compartmentalconcentration(mEq/L)PlasmaPlasmaInterstitialfluidInterstitialfluidIntracellularfluidIntracellularfluidPositiveionPositiveionNaNa++1421401014214010KK++5515055150CaCa2+2+550.0001550.0001MgMg2+2+33403340Total155153200Total155153200NegativeionNegativeionClCl10311231031123HCOHCO33272810272810HPOHPO44222414224142SOSO4422125125Organicacid66—Organicacid66—Protein(PrProtein(Pr)16140)16140TotalTotal155153200155153200渗透压高渗透压高渗透压低渗透压低⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙⊙H2OH2OH2OH2OH2OH2OH2OH2O渗透压渗透压H2O如相邻两个体液腔隙的静水压相等,而体液中溶质的浓如相邻两个体液腔隙的静水压相等,而体液中溶质的浓度不同,那么水将由溶质浓度低的腔隙向溶质浓度高的腔隙度不同,那么水将由溶质浓度低的腔隙向溶质浓度高的腔隙转移,推动水渗透的力称为渗透压。转移,推动水渗透的力称为渗透压。水、电解质紊乱水、电解质紊乱【【渗透压渗透压】】((OsmoticOsmoticpressurpressuree))Osmosisisthenetdiffusionofwateracrossaselectivelypermeablemembranefromaregionofhighwaterconcentrationtoonethathasalowerwaterconcentration.细胞内外液体调节细胞内外液体调节血浆与细胞间液调节血浆与细胞间...