WorldJournalofAcupuncture-Moxibustion(WJAM),Vol.20,No.4,30thDec.2010・1・ClinicalResearchEffectofacupunctureatBǎihuì(百会GV20)andZúsānlǐ(足三里ST36)onthelevelofseruminflammatorycytokinesinpatientswithdepression*※针刺百会、足三里对抑郁症患者血清炎性细胞因子水平的影响*※SUNHua(孙华)1ZHAOHui(赵慧)2ZHANGJie(张捷)3BAOFei(包飞)1WEIJing(魏镜)1WANGDao-hai(王道海)1ZHANGYun-xiang(张云祥)11.DepartmentofTCM,PekingUnionMedicalCollegeHospital,ChineseAcademyofMedicalSciences,Beijing100730,China；2.InstituteofBasicMedicalSciences,ChineseAcadamyofMedicalSciencesandSchoolofBasicMedicine,PekingUnionMedicalCollege；3.BeijingHospitalofTCM（1.中国医学科学院北京协和医学院北京协和医院中医科,北京100730,中国；2.中国医学科学院基础医学研究所北京协和医学院基础学院;3.北京中医医院）ABSTRACTObjectiveToinvestigatetheimmunologicmechanismofacupunctureatBǎihuì(百会GV20)andZúsānlǐ(足三里ST36)fortreatmentofdepression.MethodsEighty-fourcasesofdepressionpatientswererandomlydividedintoanelectroacupunctureobservationgroup(groupA),anelectroacupuncturecontrolgroup(groupB)andamedicationcontrolgroup(groupC),28casesineachgroup.Bǎihuì(百会GV20)andZúsānlǐ(足三里ST36)wereusedinthegroupA;Tàichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Nèiguān(内关PC6)andShénmén(神门HT7)wereusedinthegroupB;andthegroupCwastreatedwithoraladministrationofFluoxetine.ThescoresofHamiltonDepressionScale(HAMD)weretestedandthelevelofseruminterleukin1(IL-1β),interleukin6(IL-6),andtumornecrosisfactorα(TNF-α)weremeasuredbyEnzymeLinkedImmunosorbentAssay（ELISA）beforeandaftertreatment.ResultsTheirscoresofHAMDwereobviouslydecreasedaftertreatmentinthreegroups(allP<0.01).InthegroupA,2caseswerecured,19casesweremarkedlyeffective,5caseswereeffectiveand2caseswerefailed.InthegroupB,16casesweremarkedlyeffective,12caseswereeffective.WhileinthegroupC,1casewascured,17casesweremarkedlyeffective,7caseswereeffectiveand3caseswerefailed.ThegradedistributionofclinicaleffectshowedthattheeffectofgroupAwasbetter(P<0.05).ThelevelsofserumIL-1βandIL-6inthethreegroupswereobviouslydecreasedaftertreatment(P<0.05,P<0.01),whiletherewasnosignificantdifferencebetweenthelevelofserumTNF-αbeforeandaftertreatment.ConclusionTheeffectofelectroacupunctureobservationgroupissuperiortothoseofelectroacupuncturecontrolgroupandmedicationcontrolgroup.AllofthesethreemethodscancleartheinflammatorycytokinessuchasIL-1βandIL-6awayandimprovethesymptomsofdepression.————————————*SupportedbyTheSpecificChineseMedicineProjectofChineseMedicalScienceandTechnology,TheStateAdministrationofTraditionalChineseMedicine:04-05LP10※ThispaperhaswontheExcellenceofAcademyYearin2009,ChinaAcupunctureandMoxibustionAssociation.Firstauthor:SUNHua(1957-),female,chiefphysician.Researchfield:treatmentofcerebrovasculardiseaseanddepressionwithacupunctureandmoxibustion.E-mail:sunhuahe@vip.sina.comThispaperwasfirstlypublishedinZhongguoZhenjiu(ChinAcup-Mox,Chin)inChinese,2010,3WorldJournalofAcupuncture-Moxibustion(WJAM),Vol.20,No.4,30thDec.2010・2・KEYWORDSDepression;AcupunctureTherapy;PointGV20(Bǎihuì);PointST36(Zúsānlǐ);Interleukin-1;Interleukin-6[摘要]目的：探讨电针百会、足三里治疗抑郁症的免疫机制。方法：将84例患者随机分为电针观察组、电针对照组、药物对照组，每组28例。电针观察组穴取百会、足三里；电针对照组穴取太冲、三阴交、内关、神门；药物对照组给予百优解口服。在治疗前后分别用汉密尔顿抑郁...
